{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205057788288.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5980/jpnjurol1989.91.630"}},{"identifier":{"@type":"PMID","@value":"11068427"}},{"identifier":{"@type":"NAID","@value":"110003060624"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2001067983"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"ANALYSIS OF SERUM SOLUBLE INTERFERON α/β RECEPTOR LEVELS IN PATIENTS WITH UROLOGICAL DISEASES"},{"@language":"ja","@value":"泌尿器科疾患における血清中可溶性インターフェロンα/βレセプターの意義"},{"@value":"ANALYSIS OF SERUM SOLUBLE INTERFERON ^|^alpha;/^|^beta; RECEPTOR LEVELS IN PATIENTS WITH UROLOGICAL DISEASES"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"(Purpose) In order to define the clinical significance of serum soluble Interferon α/β receptor (sIFN α/βR) levels, we determined sIFN α/βR concentrations in serum of patients with urological benign and malignant diseases.<br>(Materials and Methods) Serum sIFN α/βR levels were measured in normal control (n=2), patients with benign diseases (n=50) included urolithiasis (n=16), prostatic hypertrophy (n=13), and malignant diseases included bladder cancer (n=49), renal cell carcinoma (n=30) and prostate cancer (n=36) by the enzyme linked immunosolbent assay (ELISA) using monoclonal and polyclonal antibodies. The levels of serum sIFN α/βR was correlated with the results of other hematoserological examinations, and clinical or pathological characters of each urological malignancies.<br>(Results) The serum sIFN α/βR levels (pg/ml) of patients with urolithiasis (2, 370.6±640.6, p=0.0002), benign prostatic hypertrophy (2, 121.1±550.6, p=0.0103), bladder cancer (2, 512.3±1, 012.3, p=0.0006), renal cell carcinoma (2, 686.4±1, 510.9, p=0.0046), prostate cancer (3, 188.7±1, 788., p=0.0003) showed significantly higher values than those of controls (1, 709.5±346.7). Moreover, we found statistically significant correlations among serum creatinine (Cr) levels and sIFN α/βR levels. However, there were no correlations between the sIFN α/βR levels and clinical stage, or histological grade in the patients with bladder cancer or prostate cancer, whenever the levels of sIFN α/βR were corrected by serum Cr levels. On the other hand, high level of corrected serum sIFN α/βR was observed in patients with high stage or high grade renal cell carcinoma, but not significant statistically.<br>(Conclusions) Elevated serum sIFN α/βR was observed in patients with urological disease. Further examinations should be necessary to determine the clinical usefulness of serum sIFN α/βR."},{"@language":"ja","@value":"(目的) 泌尿器科疾患における可溶性インターフェロンα/βレセプター (soluble Interferon-α/βreceptor: sIFNα/βR) に関する検討はまだ十分なされていない. 今回, ポリクローナル抗体およびモノクローナル抗体を用いたサンドイッチ Enzyme Linked Immunosolbent Assay (ELISA) 法による細胞膜外部分のsIFNα/βRの測定系が確立されたので, 各種泌尿器科良性疾患, 膀胱癌, 腎細胞癌, 前立腺癌の血清中sIFNα/βRを測定し臨床的意義について検討を行った.<br>(対象と方法) 健常コントロール22例, 良性疾患50例 (尿路結石症16例, 前立腺肥大症13例, その他21例), 膀胱癌49例, 腎細胞癌30例, 前立腺癌36例を対象として, 血清中sIFNα/βR値をELISA法により測定した. 臨床検査値との相関, 各疾患群における血清中 sIFNα/βR値の比較, さらには悪性腫瘍患者における臨床病理像との比較解析を行った.<br>(結果) 各疾患における血清中 sIFNα/βR値 (pg/ml) は, 健常コントロール (1,709.5±346.7) に比し, 尿路結石症 (2,370.6±640.6, p=0.0002), 前立腺肥大症 (2,121.1±550.6, p=0.0103), 膀胱癌 (2,512.3±1,012.3, p=0.0006), 腎細胞癌 (2,686.4±1,510.9, p=0.0046), 前立腺癌 (3,188.7±1,788.0, p=0.0003) ともに, 有意に高値を示した. 各種血液学的検査結果との比較では, 血清中クレアチニン値との相関が認められたが, その他の検査結果との相関は認めなかった. また, 血清中 sIFNα/βR値と膀胱癌および前立腺癌における臨床病理像との比較では, 実測値および血清中クレアチニン値による補正値 (Cr補正値) ともに有意な相関は認めなかった. 一方, 腎細胞癌では, 進行例および異型度の強い症例においてCr補正値が高値を示したが, 統計学的に有意ではなかった.<br>(結論) 血清中sIFNα/βR値は各種泌尿器科疾患において高値を示した. 血清中 sIFNα/βR値の臨床応用の可能性を評価するためには, 今後さらに多数例における詳細な検討が必要と思われた."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658362260993","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10214446"},{"@type":"NRID","@value":"1000010214446"},{"@type":"NRID","@value":"9000005833312"},{"@type":"NRID","@value":"9000003195674"},{"@type":"NRID","@value":"9000403050562"},{"@type":"NRID","@value":"9000018571509"},{"@type":"NRID","@value":"9000408776047"},{"@type":"NRID","@value":"9000280541796"},{"@type":"NRID","@value":"9000383211986"},{"@type":"NRID","@value":"9000023749601"},{"@type":"NRID","@value":"9000280541905"},{"@type":"NRID","@value":"9000375920039"},{"@type":"NRID","@value":"9000399597902"},{"@type":"NRID","@value":"9000004656802"},{"@type":"NRID","@value":"9000283653886"},{"@type":"NRID","@value":"9000409882984"},{"@type":"NRID","@value":"9000242581770"},{"@type":"NRID","@value":"9000396110077"},{"@type":"NRID","@value":"9000397656179"},{"@type":"NRID","@value":"9000378657050"},{"@type":"NRID","@value":"9000020373531"},{"@type":"NRID","@value":"9000391738716"},{"@type":"NRID","@value":"9000257900604"},{"@type":"NRID","@value":"9000283564334"},{"@type":"NRID","@value":"9000398634718"},{"@type":"NRID","@value":"9000010184538"},{"@type":"NRID","@value":"9000024998181"},{"@type":"NRID","@value":"9000335182979"},{"@type":"NRID","@value":"9000344125819"},{"@type":"NRID","@value":"9000024300678"},{"@type":"NRID","@value":"9000023529483"},{"@type":"NRID","@value":"9000397711740"},{"@type":"NRID","@value":"9000024998198"},{"@type":"NRID","@value":"9000314400073"},{"@type":"NRID","@value":"9000024423354"},{"@type":"NRID","@value":"9000391753007"},{"@type":"NRID","@value":"9000257773047"},{"@type":"NRID","@value":"9000257772678"},{"@type":"NRID","@value":"9000380482357"},{"@type":"NRID","@value":"9000383211953"},{"@type":"NRID","@value":"9000024301445"},{"@type":"NRID","@value":"9000257900632"},{"@type":"NRID","@value":"9000283563411"},{"@type":"NRID","@value":"9000242165774"},{"@type":"NRID","@value":"9000344125820"},{"@type":"NRID","@value":"9000242460037"},{"@type":"NRID","@value":"9000257901304"},{"@type":"NRID","@value":"9000242674681"},{"@type":"NRID","@value":"9000021997966"},{"@type":"NRID","@value":"9000257901279"},{"@type":"NRID","@value":"9000356659551"},{"@type":"NRID","@value":"9000399597796"},{"@type":"NRID","@value":"9000024300023"},{"@type":"NRID","@value":"9000023632933"},{"@type":"NRID","@value":"9000403405269"},{"@type":"NRID","@value":"9000242165811"},{"@type":"NRID","@value":"9000314400163"},{"@type":"NRID","@value":"9000399597763"},{"@type":"NRID","@value":"9000023768314"},{"@type":"NRID","@value":"9000411278086"},{"@type":"NRID","@value":"9000283713893"},{"@type":"NRID","@value":"9000403405206"},{"@type":"NRID","@value":"9000403405376"},{"@type":"NRID","@value":"9000255744030"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0017318"}],"foaf:name":[{"@language":"en","@value":"Kanayama Hiro-omi"},{"@language":"ja","@value":"金山 博臣"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, University of Tokushima School of Medicine"},{"@language":"ja","@value":"徳島大学医学部泌尿器科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205057788288","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Takahashi Masayuki"},{"@language":"ja","@value":"高橋 正幸"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島大学医学部泌尿器科"},{"@language":"en","@value":"Department of Urology, University of Tokushima School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658466276865","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40304521"},{"@type":"NRID","@value":"1000040304521"},{"@type":"NRID","@value":"9000334430726"},{"@type":"NRID","@value":"9000254095563"},{"@type":"NRID","@value":"9000024301441"},{"@type":"NRID","@value":"9000254095911"},{"@type":"NRID","@value":"9000023523286"},{"@type":"NRID","@value":"9000254507850"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054342"}],"foaf:name":[{"@language":"en","@value":"Nishitani Masaaki"},{"@language":"ja","@value":"西谷 真明"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, University of Tokushima School of 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Susumu"},{"@language":"ja","@value":"香川 征"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Urology, University of Tokushima School of Medicine"},{"@language":"ja","@value":"徳島大学医学部泌尿器科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00215287"},{"@type":"EISSN","@value":"18847110"},{"@type":"NCID","@value":"AN00196577"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese Journal of Urology"},{"@language":"ja","@value":"日本泌尿器科学会雑誌"},{"@language":"en","@value":"Jpn. j. urol"},{"@language":"ja","@value":"日泌尿会誌"}],"dc:publisher":[{"@language":"en","@value":"THE JAPANESE UROLOGICAL ASSOCIATION"},{"@language":"ja","@value":"一般社団法人 日本泌尿器科学会"}],"prism:publicationDate":"2000","prism:volume":"91","prism:number":"9","prism:startingPage":"630","prism:endingPage":"636"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://search.jamas.or.jp/link/ui/2001067983"}],"availableAt":"2000","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=serum%20soluble%20Interferon%20%CE%B1/%CE%B2%20receptor","dc:title":"serum soluble Interferon α/β receptor"},{"@id":"https://cir.nii.ac.jp/all?q=urological%20disease","dc:title":"urological disease"},{"@id":"https://cir.nii.ac.jp/all?q=clinical%20usefulness","dc:title":"clinical usefulness"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%8F%AF%E6%BA%B6%E6%80%A7%E3%82%A4%E3%83%B3%E3%82%BF%E3%83%BC%E3%83%95%E3%82%A7%E3%83%AD%E3%83%B3%CE%B1/%CE%B2%E3%83%AC%E3%82%BB%E3%83%97%E3%82%BF%E3%83%BC","dc:title":"可溶性インターフェロンα/βレセプター"},{"@id":"https://cir.nii.ac.jp/all?q=%E6%B3%8C%E5%B0%BF%E5%99%A8%E7%A7%91%E7%96%BE%E6%82%A3","dc:title":"泌尿器科疾患"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%87%A8%E5%BA%8A%E5%BF%9C%E7%94%A8","dc:title":"臨床応用"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1364233271065555584","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Serum levels of soluble interferon alfa/beta receptor as an inhibitory factor of interferon in the patients with chronic hepatitis C"}]},{"@id":"https://cir.nii.ac.jp/crid/1520010380013598336","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"遺伝子操作を用いた新規生理活性物質の発現と測定系の確立"},{"@language":"ja-Kana","@value":"イデンシ ソウサ オ モチイタ シンキ セイリ カッセイ ブッシツ ノ 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Mouse interferon and Cholera toxin do not compete for the common receptor site ofα/βinterferon"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026562037760","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Soluble interferon-α receptor molecules are present in body fluids"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543026583256448","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons α and β and alters macrophage responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976298540928","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antibodies to a surface component coded by human chromosome 21 inhibit action of interferon"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976497043200","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic transfer of a functional human interferon alpha receptor into mouse cells : Cloning and expression of its cDNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924155787264","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950401153794176","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"High-affinity binding of 125I-labeled mouse interferon to a specific cell surface receptor"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0008908671"},{"@type":"CROSSREF","@value":"10.5980/jpnjurol1989.91.630"},{"@type":"PUBMED","@value":"11068427"},{"@type":"CIA","@value":"110003060624"},{"@type":"OPENAIRE","@value":"doi_dedup___::1f464b818286dff32c9bb96e600d534f"}]}