Evaluation of Transmural Myocardial Perfusion by Ultra-Harmonic Myocardial Contrast Echocardiography in Reperfused Acute Myocardial Infarction

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  • Wada Hiroshi
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Yasu Takanori
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Kotsuka Hiroyuki
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Hayakawa Yuhki
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Tsukamoto Yoshiaki
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Kobayashi Nobuhiko
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Ishida Takeshi
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Kobayashi Yasuyuki
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Kubo Norifumi
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Kawakami Masanobu
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School
  • Saito Muneyasu
    First Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School

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Description

Background The transmural distribution of myocardial perfusion is important for predicting the contractile reverse of an infarcted wall in reperfused acute myocardial infarction (AMI). Evaluating transmural myocardial perfusion by myocardial contrast echocardiography (MCE) could predict the long-term recovery of left ventricular (LV) function. Methods and Results The study group comprised 20 consecutive patients with a first-episode anterior AMI with total occlusion of the proximal left anterior descending artery, who underwent successful percutaneous coronary intervention within 24 h of onset. MCE was performed on the 15th day after the onset, using ultraharmonic gray-scale imaging with intermittent end-systolic triggering every 4 beats or every 6 beats. Regions of interest were placed over both the endocardial and epicardial region at the mid-septal level. Regional wall motion (RWM) of the infarcted anterior wall and global LV function were assessed by 2-dimensional echocardiography and left ventriculography in both the acute and chronic phase. The transmural distribution of myocardial perfusion by MCE demonstrated a significant relation with RWM score index (r=0.75, p=0.0004). Recovery of RWM and LV ejection fraction (LVEF) at 6 months after reperfusion was significantly greater in the group with good perfusion of the epicardium according to MCE than in the poor perfusion group [RWM (SD/cord); -1.23±0.91 vs -3.51±0.84, p=0.001, LVEF (%); 63.8±10.4 vs 47.0±3.4, p=0.04]. Conclusions Assessing the transmural distribution of myocardial perfusion by MCE can predict the long-term recovery of LV function after a reperfused AMI. (Circ J 2005; 69: 1041 - 1046)<br>

Journal

  • Circulation Journal

    Circulation Journal 69 (9), 1041-1046, 2005

    The Japanese Circulation Society

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