{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205193161856.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2508/chikusan.76.331"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"7458094"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/7458094"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I7458094"}},{"identifier":{"@type":"NAID","@value":"10025838428"}},{"identifier":{"@type":"NAID","@value":"30021763577"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2006011463"}}],"dc:title":[{"@language":"en","@value":"Oral Administrations with Propylene Glycol and the Gestation Length of High Producing Holstein Dairy Cows"},{"@language":"ja","@value":"分娩前のホルスタイン種高泌乳牛に対するプロピレングリコール投与と妊娠日数"},{"@language":"ja-Kana","@value":"ブンベン マエ ノ ホルスタインシュ コウヒツニュウギュウ ニ タイスル プロピレングリコール トウヨ ト ニンシン ニッスウ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Average length of gestation of Holstein dairy cows is known as 279 days, however, the individual difference of this parameter is large and required to be smaller in order to avoid the accident related to the dystocia, and to manage precisely the high producing dairy cows around parturition.  Propylene glycol can become the precursor for gluconeogenesis in the liver, and it is commonly administered as an oral drench for the dairy cows around parturition.  In this report using the oral drench of propylene glycol for prepartum Holstein high producing dairy cows, we discovered that the administration might prolong the gestation length of the cows.  Cows were given a 500ml oral drench of propylene glycol (Propylene glycol group, n=10) or water (Water group, n=10) once every other day from 3 weeks prior to the expected calving date until parturition.  Blood samples were collected 3 hour after the drench to measure the plasma concentrations of metabolites, insulin, IGF-I, leptin, cortisol, progesterone and estrogen.  All cows of the both groups calved single calf without the dystocia.  The gestation length were 280.4±0.8 days in the Propylene glycol group, and 277.0±1.0 days in the Water group, and the 3.4 days of difference was significant (P=0.015).  The propylene glycol drench increased the concentrations of glucose (P=0.0001) and insulin (P<0.01), and decreased the FFA level (P<0.05) significantly.  Thus, the difference in the concentrations of insulin, glucose and FFA in the blood after the propylene glycol drench may relate to the observed extension effect of the drench on the gestation length in the high producing Holstein dairy cows."},{"@language":"ja","@value":"ホルスタイン種乳牛の妊娠日数には個体差があり，個体差が生じる原因の解明が必要である．筆者は分娩前の経産ホルスタイン種乳牛にVFA類似の糖源性溶液であるプロピレングリコールを経口投与する実験の中で，プロピレングリコール投与群と水投与群の間で妊娠日数の有意差を観察したので報告する．この実験では分娩予定日の3週間前より分娩日まで隔日に500mlのプロピレングリコールまたは水を経口投与し，毎回投与の3時間後に採血した．全供試牛は単子を正常分娩したが，プロピレングリコール投与群（280.4±0.8日）と水投与群（277.0±1.0日）の妊娠日数には3.4日の有意差（P＜0.05）が認められた．プロピレングリコール投与群では血漿中のグルコース（P＝0.0001）とインスリン（P＜0.01）濃度が高く，FFA濃度が低かった（P＜0.05）．IGF-I，レプチン，コルチゾルなどには群間差は無かった．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326235983104","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80370592"},{"@type":"NRID","@value":"1000080370592"},{"@type":"NRID","@value":"9000018276612"},{"@type":"NRID","@value":"9000347225405"},{"@type":"NRID","@value":"9000415048767"},{"@type":"NRID","@value":"9000010561101"},{"@type":"NRID","@value":"9000006375148"},{"@type":"NRID","@value":"9000018276163"},{"@type":"NRID","@value":"9000021089833"},{"@type":"NRID","@value":"9000020903942"},{"@type":"NRID","@value":"9000345195232"},{"@type":"NRID","@value":"9000347103570"},{"@type":"NRID","@value":"9000410476874"},{"@type":"NRID","@value":"9000259832541"},{"@type":"NRID","@value":"9000001361452"},{"@type":"NRID","@value":"9000414091749"},{"@type":"NRID","@value":"9000317150376"},{"@type":"NRID","@value":"9000403963030"},{"@type":"NRID","@value":"9000356509355"},{"@type":"NRID","@value":"9000275824682"},{"@type":"NRID","@value":"9000337094402"},{"@type":"NRID","@value":"9000018475631"},{"@type":"NRID","@value":"9000410476800"},{"@type":"NRID","@value":"9000409901607"},{"@type":"NRID","@value":"9000396160481"},{"@type":"NRID","@value":"9000347224939"},{"@type":"NRID","@value":"9000392763618"},{"@type":"NRID","@value":"9000020970820"},{"@type":"NRID","@value":"9000403963029"},{"@type":"NRID","@value":"9000404511556"},{"@type":"NRID","@value":"9000414091747"},{"@type":"NRID","@value":"9000403963033"},{"@type":"NRID","@value":"9000325827457"},{"@type":"NRID","@value":"9000392068602"},{"@type":"NRID","@value":"9000403963022"},{"@type":"NRID","@value":"9000002065463"},{"@type":"NRID","@value":"9000409902419"},{"@type":"NRID","@value":"9000403963028"},{"@type":"NRID","@value":"9000403843321"},{"@type":"NRID","@value":"9000368937000"},{"@type":"NRID","@value":"9000347225432"},{"@type":"NRID","@value":"9000398256942"},{"@type":"NRID","@value":"9000021033061"},{"@type":"NRID","@value":"9000347224937"},{"@type":"NRID","@value":"9000315680644"},{"@type":"NRID","@value":"9000018276628"},{"@type":"NRID","@value":"9000403963023"},{"@type":"NRID","@value":"9000007044463"},{"@type":"NRID","@value":"9000412386698"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/HiroyaKadokawa"}],"foaf:name":[{"@language":"en","@value":"KADOKAWA Hiroya"},{"@language":"ja","@value":"角川 博哉"}],"jpcoar:affiliationName":[{"@language":"en","@value":"National Institute of Livestock and Grassland Science"},{"@language":"ja","@value":"畜産草地研究所"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204340334083","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001361456"}],"foaf:name":[{"@language":"en","@value":"YAMADA Yutaka"},{"@language":"ja","@value":"山田 豊"}],"jpcoar:affiliationName":[{"@language":"en","@value":"National Institute of Livestock and Grassland Science"},{"@language":"ja","@value":"畜産草地研究所"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1346907X"},{"@type":"EISSN","@value":"18808255"},{"@type":"CODEN","@value":"NICKA3"},{"@type":"NDL_BIB_ID","@value":"000000018714"},{"@type":"ISSN","@value":"1346907X"},{"@type":"LISSN","@value":"00215309"},{"@type":"NCID","@value":"AN00195188"}],"prism:publicationName":[{"@language":"en","@value":"Nihon Chikusan Gakkaiho"},{"@language":"ja","@value":"日本畜産学会報"},{"@language":"en","@value":"Nihon Chikusan Gakkaiho"},{"@language":"ja","@value":"日畜会報"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Animal Science"},{"@language":"ja","@value":"公益社団法人 日本畜産学会"}],"prism:publicationDate":"2005","prism:volume":"76","prism:number":"3","prism:startingPage":"331","prism:endingPage":"338"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/7458094"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I7458094"},{"@id":"https://search.jamas.or.jp/link/ui/2006011463"}],"availableAt":"2005","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=VFA","dc:title":"VFA"},{"@id":"https://cir.nii.ac.jp/all?q=energy%20status","dc:title":"energy status"},{"@id":"https://cir.nii.ac.jp/all?q=parturition","dc:title":"parturition"},{"@id":"https://cir.nii.ac.jp/all?q=insulin","dc:title":"insulin"},{"@id":"https://cir.nii.ac.jp/all?q=glucose","dc:title":"glucose"},{"@id":"https://cir.nii.ac.jp/all?q=leptin","dc:title":"leptin"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564288585001856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"牛血漿中プロジェステロンの酵素免疫測定法"},{"@language":"ja-Kana","@value":"ウシ ケッショウチュウ プロジェステロン ノ コウソ メンエキ ソクテイホウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143734615040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Prepartum Propylene Glycol Administration on Periparturient Fatty Liver in Dairy Cows"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144714673536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of nutritional 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adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681312947200","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Simple Defatting Method Using a Partition Method of Acetonitorile and n-Hexan for Radioimmunoassay of Low Blood Levels of Estradiol-17β"},{"@language":"ja","@value":"アセトニトリル・n-ヘキサン分配法を用いた低濃度の血中エストラジオール-17β測定のための簡便な脱脂法"},{"@language":"ja-Kana","@value":"アセトニトリル n ヘキサン ブンパイホウ オ モチイタ テイ ノウド ノ ケ"},{"@value":"A simple defatting method using a partition method of acetonitrile and n-hexane for radioimmunoassay of low blood levels of estradiol- 17b"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750947281152","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Propylene glycol and glycerol as a feed additive for lactating dairy cows : an evaluation of blood metabolite parameters"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750947282688","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Peripartal propylene glycol supplementation and mtabolism, animal health, fertility, and production in dairy cows"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700900702208","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Radioimmunoassay for Insulin-like growth factor-I : solutions to some potential problems and pitfalls"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600807548800","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of propylene glycol or glycerol supplementation of the diet of dairy cows on feed intake, milk yield and composition, and incidence of 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