殺ダニ剤AKD-2023とその脱アセチル代謝物のミトコンドリア呼吸鎖電子伝達阻害機構

DOI NDLデジタルコレクション 日本農学文献記事索引 Web Site Web Site 被引用文献3件 参考文献15件

書誌事項

タイトル別名
  • Respiratory Inhibition of Acaricide AKD-2023 and Its Deacetyl Metabolite
  • Respiratory Inhibition of Acaricide AKD

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説明

To define acaricidal mechanism of a new acaricidal AKD-2023 (2-acetoxy-3-n-dodecyl-1, 4-naphthoquinone) and its metabolite, DHN (2-hydroxy-3-n-dodecyl-1, 4-naphthoquinone), the effects of these compounds on the respiration of flight-muscle mitochondria isolated from house flies were investigated. The inhibitory potency of AKD-2023 for succinate and pyruvate oxidation activity was much less than that of DHN. This result suggested that the hydrolyzed metabolite, DHN is virtually biologically active and inhibits the respiration of mitochondria. It was also proved that the inhibition occurs at the complex III in mitochondrial electron transfer chain. On the basis of reduction kinetics of cytochromes b and c1, the binding site was shown to be ubiquinol oxidation site (Q0 center) of complex III, being different from that of other acaricides developed recently.

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