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Inhibitory Effect of Chaga (Inonotus obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis

  • AKITA Ayako
    Research Unit of Selfmedication, School of Pharmacy, Nihon University
  • YASUKAWA Ken
    Research Unit of Selfmedication, School of Pharmacy, Nihon University

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  • チャーガ(カバノアナタケ)のマウス皮膚二段階発癌実験の腫瘍抑制効果

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Abstract

Chaga (the sclerotia of Inonotus obliquus) has been widely used as a folk medicine in the treatment of cancer, cardiovascular disease and diabetes in Russia, Poland, and several Baltic countries. More recently, this herb has been assessed for its cancer-preventing activity. Using a mouse model of skin cancer, oral administration of Chaga was found to inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate following initiation with 7,12-dimethylbenz[a]anthracene in mouse skin.<br>

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