Pilot Study of Antioxidant Mixture (Vitamin E, Pycnogenol and Squalene) in Healthy Smokers: Inhibitory Effect on Oxidative DNA Damage

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  • OHNO Satoshi
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science Department of Molecular Reproductive Biology, Kanazawa University, Graduate School of Medical Science
  • OHNO Yumiko
    Department of Molecular Reproductive Biology, Kanazawa University, Graduate School of Medical Science
  • SUZUKI Nobutaka
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science Department of Molecular Reproductive Biology, Kanazawa University, Graduate School of Medical Science
  • KAWAGOE Nobuhide
    SRL, Inc.
  • ARAI Takanari
    Center for the Advancement of Pregnancy, Perinatal and Infant Care, Kanazawa University Hospital
  • INOUE Masaki
    Department of Molecular Reproductive Biology, Kanazawa University, Graduate School of Medical Science

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  • 健常喫煙者における抗酸化天然成分によるパイロット試験：DNA 酸化傷害抑制効果の検討

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Abstract

Oxidative stress is considered to contribute to degenerative disease. The urinary excretion of the DNA repair product 8-hydroxy-2′-deoxyguanosine (8-OHdG) is proposed as a noninvasive biomarker of current oxidative stress in vivo. We investigated the effect of an antioxidant mixture on urinary 8-OHdG excretions in 12 otherwise healthy smokers. During the intervention period for 2 weeks, subjects consumed four capsules of PICACE® (Pycnogenol® 15 mg/capsule, Vitamin E; 56.1 mg/capsule, Squalene; 138.9 mg/capsule) per day. On days 0 (pre-internal use), 3, 7, 14, and 44, morning urine samples were collected. The urinary 8-OHdG was measured using high-performance liquid chromatography (HPLC). The urinary 8-OHdG level on day 3 was significantly reduced compared to day 0. The level of 8-OHdG after a washout period for PICACE® (days 44) returned to day 0 baseline. These preliminary data suggest that PICACE® supplements can protect smokers from oxidative stress and possibly reduce disease risk caused by free radicals associated with smoking.<br>

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