{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205222088960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5981/jjhnc.38.323"}},{"identifier":{"@type":"NAID","@value":"10031170531"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013011202"}}],"dc:title":[{"@language":"en","@value":"A clinical study of 152 cases of glottic cancer"},{"@language":"ja","@value":"声門癌152例の臨床統計的検討"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"One hundred fifty-two cases of glottic squamous cell carcinoma primarily treated in our hospital as inpatients during 22 years between 1989 and 2011 were retrospectively studied. They had been comprehensively treated with X-rays radiation in all cases (median dose 66 Gy), with chemotherapy in 69 cases (fluorouracil + carboplatin administered as induction chemotherapy (ICT) or concurrent chemoradiotherapy (CCRT)), followed by total laryngectomy if unavoidable.<br>Their median age was 67.0 years ranging from 38 to 89, and the male to female ratio was 37:1 and median observation time was 71.5 months. According to the 6th edition of the UICC classification, there were 75 cases with Stage I, 43 cases with Stage II, 25 cases with Stage III, and 9 cases with Stage IV. For all cases, the 5-year cause-specific survival rate and 5-year overall survival rate were 91.7% (95% CI, 85.0-98.4) and 82.3% (95% CI, 73.5-91.1). In each stage, both rates were 95.2/88.4% with Stage I, 100/83.6% with Stage II, 86.7/75.9% with Stage III, and 44.4/44.4% with Stage IV, which were identified as statistically significant (p < 0.0001). Three types of histopathological differentiation in squamous cell carcinoma were not found to contribute to the statistically significant difference in the prognosis of glottic cancers.<br>Laryngeal preservation rate at 5 years in all cases was 73.2% (95% CI, 65.3-81.1). Regarding T-stages, the rates were 84.4% with T1, 81.6% with T2, 32.1% with T3 and 0% with T4 (p < 0.0001). Furthermore, we clarified that there was no statistically significant difference between 5-year CSS rates in the two groups of laryngectomy cases and non-laryngectomy cases in the stages of T3 and T4 (p = 0.6948).<br>Our data were dissolved to be statistically not recessive in comparison with other data retrieved from six institutes, and showed the possibility of preservation of the larynx in T3 cases if sufficiently comprehensive treatment such as CCRT is carried out."},{"@language":"ja","@value":"22年間に入院治療した声門扁平上皮癌一次治療152例を対象として検討した。年齢の中央値は67.0歳であり，男女比は37：1であり，Stage分類では，Stage I 75例，II 43例，III 25例，IV 9例（IVA 6例・IVB 1例・IVC 2例）であった。治療法は全例にX線照射を，69例に全身化学療法を導入化学療法または抗癌剤放射線治療同時併用でおこなった。原発巣には，レーザー手術または喉頭全摘術を施行した。全例の5年疾患特異的生存率（CSS）は91.7%，5年累積粗生存率（OS）は82.3%であり，Stage別5年CSSは，I 95.2%，II 100%，III 86.7%，IV 44.4%であった。5年喉頭温存率は73.2%，T分類別では，T1 84.4%，T2 81.6%，T3 32.1%，T4 0%であった。さらに他施設の生存率，喉頭温存率と比較したが劣性は認めなかったのみならず，T3症例において喉頭温存率が高かった。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410009221407885824","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000258079550"},{"@type":"NRID","@value":"9000019195222"}],"foaf:name":[{"@language":"en","@value":"Hiraga Yukihiro"},{"@language":"ja","@value":"平賀 幸弘"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Otolaryngology, Yamanashi Prefectural Central Hospital"},{"@language":"ja","@value":"山梨県立中央病院耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221407885825","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000258079551"},{"@type":"NRID","@value":"9000017405106"}],"foaf:name":[{"@language":"en","@value":"Kou Junichi"},{"@language":"ja","@value":"黄 淳一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Otolaryngology, Yamanashi Prefectural Central Hospital"},{"@language":"ja","@value":"山梨県立中央病院耳鼻咽喉科"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13495747"},{"@type":"EISSN","@value":"18818382"},{"@type":"NCID","@value":"AA11985555"}],"prism:publicationName":[{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"},{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Head and Neck Cancer"},{"@language":"ja","@value":"日本頭頸部癌学会"}],"prism:publicationDate":"2012","prism:volume":"38","prism:number":"3","prism:startingPage":"323","prism:endingPage":"330"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2013011202"}],"availableAt":"2012","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Glottic%20cancer","dc:title":"Glottic cancer"},{"@id":"https://cir.nii.ac.jp/all?q=Comprehensive%20treatment","dc:title":"Comprehensive treatment"},{"@id":"https://cir.nii.ac.jp/all?q=5-year%20survival%20rate","dc:title":"5-year survival rate"},{"@id":"https://cir.nii.ac.jp/all?q=Preservasion%20rate%20of%20larynx","dc:title":"Preservasion rate of larynx"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A3%B0%E9%96%80%E7%99%8C","dc:title":"声門癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%9B%86%E5%AD%A6%E7%9A%84%E6%B2%BB%E7%99%82","dc:title":"集学的治療"},{"@id":"https://cir.nii.ac.jp/all?q=5%E5%B9%B4%E7%94%9F%E5%AD%98%E7%8E%87","dc:title":"5年生存率"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%96%89%E9%A0%AD%E6%B8%A9%E5%AD%98%E7%8E%87","dc:title":"喉頭温存率"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1362262943666207360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Treatment of Early Vocal Cord Carcinoma with<sup>60</sup>CO Gamma Rays, 8/10 MV X-Rays, or 4 MV X-Rays—are the Results Different?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895218593664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204262684672","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Review of Laryngeal Cancer: a Series of 626 Cases over the Past 33 Years"},{"@value":"喉頭癌６２６例の臨床統計"},{"@language":"ja-Kana","@value":"リンショウ コウトウガン 626レイ ノ リンショウ トウケイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205004959872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Clinical Study of 1079 Patients with Laryngeal Cancer."},{"@value":"大阪府立成人病センターにおける喉頭癌１０７９例の臨床統計"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205222581120","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A clinical study of glottic carcinoma"},{"@language":"ja","@value":"当院における声門癌の臨床的検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205280815360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of chemoradiotherapy in the treatment of laryngeal cancer"},{"@value":"喉頭癌に対する化学放射線療法の役割"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205526385920","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Study of 97 Cases of Laryngeal Cancer"},{"@language":"ja","@value":"当科における喉頭癌の臨床的検討"},{"@value":"当科〔広島大学大学院耳鼻咽喉科・頭頸部外科〕における喉頭癌の臨床的検討"},{"@language":"ja-Kana","@value":"トウ カ ヒロシマ ダイガク ダイガクイン ジビ インコウカ トウケイブ ゲカ ニ オケル コウトウガン ノ リンショウテキ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679239945600","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Study of Cases of Laryngeal Cancer"},{"@value":"喉頭癌の臨床的検討"},{"@language":"ja-Kana","@value":"リンショウ コウトウ ガン ノ リンショウテキ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679240910848","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"進行喉頭癌の検討"},{"@language":"en","@value":"Clinical Study of Advanced Laryngeal Carcinoma"},{"@value":"臨床 進行喉頭癌の検討"},{"@language":"ja-Kana","@value":"リンショウ シンコウ コウトウガン ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679981675008","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Adjuvant Chemotherapy (Nedaplatin/UFT) after Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma"},{"@value":"頭頚部へん平上皮癌進行例に対する化学放射線同時併用療法後のａｄｊｕｖａｎｔ　ｃｈｅｍｏｔｈｅｒａｐｙ（Ｎｅｄａｐｌａｔｉｎ／ＵＦＴ）の検討"},{"@language":"ja-Kana","@value":"トウケイブ ヘンペイ ジョウヒガン シンコウレイ ニ タイスル カガク ホウシャセン ドウジ ヘイヨウ リョウホウ ゴ ノ adjuvant chemotherapy Nedaplatin UFT ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680198479488","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"SUPERSELECTIVE INTRA-ARTERIAL CHEMORADIOTHERAPY FOR LARYNGEAL CANCER-IS IT REASONABLE TO TREAT GLOTTIC CANCER IN A SIMILAR WAY TO SUPRAGLOTTIC CANCER?-"},{"@language":"ja","@value":"喉頭癌に対する超選択的動注化学療法―声門癌と声門上癌の治療は同じでよいか―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390305179448035200","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Local Control of Laryngeal Cancer by Radiotherapy and Boron Neutron Capture Therapy (BNCT) for Cases of Local Recurrence"},{"@language":"ja","@value":"喉頭癌の照射後局所再発例に対するホウ素中性子補足療法（BNCT）"},{"@language":"ja-Kana","@value":"コウトウ ガン ノ ショウシャ ゴ キョクショ サイハツレイ ニ タイスル ホウソ チュウセイシ ホソク リョウホウ(BNCT)"}]},{"@id":"https://cir.nii.ac.jp/crid/1520572357445879552","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"当科[秋田大学大学院医学系研究科耳鼻咽喉科]における喉頭癌の臨床的検討"},{"@language":"ja-Kana","@value":"トウ カ アキタ ダイガク ダイガクイン イガクケイ ケンキュウカ ジビ インコウカ ニ オケル コウトウガン ノ リンショウテキ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009751229608704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Phase I/II trial of concurrent use of S-1 and radiation therapy for T2 glottic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572699351563520","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Treatment of early vocal cord carcinoma with 60Co gamma rays, 8/10 MV X-rays, or 4 MV X-rays -are the results different?"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649304982656","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"放射線治療による喉頭癌および下咽頭癌の喉頭保存"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649304984832","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Effect of Overall Treatment Time of Radiotherapy to Local Control of Disease in Head and Neck Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698601089869312","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Definitive Radiation Therapy for Moderately Advanced Laryngeal Cancer : Effects of Accelerated Hyperfractionation"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499165245568","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal 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Cancer Incidence and Incidence Rates in Japan in 2005: Based on Data from 12 Population-based Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976013417088","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"N2頸部リンパ節転移の術前治療後頸部郭清による制御と病理学的検討"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399072089344","@type":"Article","relationType":["cites"]},{"@id":"https://cir.nii.ac.jp/crid/1573950400488553344","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"喉頭癌T2, T3の治療 : 喉頭亜全摘術と経口的声門上部切除術を中心に"},{"@language":"en","@value":"Function preservation surgeries for T2 and T3 laryngeal cancer : Supracricoid laryngectomy and transoral partial laryngopharyngectomy"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1001068959"},{"@type":"CROSSREF","@value":"10.5981/jjhnc.38.323"},{"@type":"CIA","@value":"10031170531"},{"@type":"CROSSREF","@value":"10.2468/jbes.76.189_references_DOI_UoeXZtSPjQmPmRiMkH1iA9ZEjtc"}]}