{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205222853248.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5981/jjhnc.38.390"}},{"identifier":{"@type":"NAID","@value":"10031170543"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013118478"}}],"dc:title":[{"@language":"en","@value":"Current status of human papilloma virus infection in oropharynx cancer"},{"@value":"わが国における中咽頭癌HPV感染の現状"}],"dcterms:alternative":[{"@language":"en","@value":"—A multicenter study in Japan"},{"@value":"―多施設共同研究から―"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The recent increase in incidence of oropharyngeal cancer in the USA and northern Europe has been attributed to human papillomavirus (HPV) infection. HPV causes an epidemiologically and clinically distinct form of oropharyngeal squamous cell carcinoma (OPSCC). The prevalence of HPV in Japanese patients with OPSCC is not clear. The Japanese Cooperative Study Group for Basic Research in Head and Neck Cancer (JCSG-BRHNC) performed a prospective study to clarify the prevalence and genotype distribution of HPV in OPSCC in Japan. Patients without prior treatments were registered from May 2009 to March 2011 and tissue samples were collected from 20 institutes. OPSCC tissue samples from 158 patients were tested using polymerase chain reaction (PCR) and Hybrid Capture II (HC2). Non-cancerous tissues from 54 patients with chronic tonsillitis or tonsil hypertrophy were also examined as controls. Results: HPV was detected in 79 (50.3%) of 157 patients and 1 of 112 control patients by PCR. HPV genotype distributions revealed HPV16 in 70 cases (88.6%). In histological features, cases with low differentiation type were dominant in HPV-positive OPSCC (p = 0.0175). The sub-sites of tumor were lateral wall (tonsil) in 73(92.4%) for HPV-positive patients and 44 (56.4%) for HPV-negative patients (p < 0.0001). The ratio of stage IV was larger in the HPV-positive patients than in the HPV-negative patients. The ratios of non-smoker and non-drinker OPSCC patients were also was larger in the HPV-positive patients than in the HPV-negative patients. Overall survival was better in HPV-positive than HPV-negative patients with stage III or IV OPSCC treated with CRT or surgery. HPV detection using HC2 using oral brushing samples revealed that sensitivity and specificity were 93.7% and 96.2%, respectively. We clarified the prevalence of HPV of OPSCC in Japanese. The clinical features and prognosis were similar to the data reported in the USA."},{"@value":"近年，中咽頭癌におけるヒトパピローマウイルス（HPV）感染が問題となっている。特に米国においては中咽頭癌の罹患率が増加しているが，その原因としてHPV陽性の中咽頭癌が増加していることが指摘されている。一方，HPV陽性の中咽頭癌はその発癌メカニズムの違いにより，生物学的な悪性度が異なることが指摘されている。今回，頭頸部癌基礎研究会において，中咽頭癌のHPV感染に関して全国レベルでの調査研究を行い，わが国の中咽頭癌症例におけるHPV感染の現状を調査した。本研究は頭頸部癌基礎研究会にて行い，2009年5月に症例の登録が開始された。HPVの検出はPCRとハイブリッドキャプチャーII法（HC2）で行った。中咽頭癌症例は157例登録され対照として正常扁桃112例が登録され解析された。対照症例のうち，HPVは1例に検出され112例は陰性であった。すなわち陽性率は0.9%であった。中咽頭扁平上皮癌の157例では79例においてPCRでHPV感染が検出されHPV感染率は50.0%であった。HPVのタイピングではHPV16が70例で88.6%を占めた。HPV感染の有無による臨床的特徴について，HPV陽性ではStage IVの割合が多く，組織学的に低分化の傾向がみられた。発生部位では側壁が92.4%とほとんどを占めた。喫煙と飲酒に関しては，HPV陽性例で非喫煙，非飲酒の割合が多かった。次にStage IIIとIVについて治療法別に予後を検討したところ全生存率でHPV陽性例が陰性例に比較して予後が良好である傾向が認められた。スクリーニングとして行ったHC2法とPCRを比較したところ感度93.7%，特異度96.2%であった。今回の研究で，わが国の中咽頭扁平上皮癌におけるHPV陽性率は50%であることがわかりその臨床的特徴も欧米で報告されているものと同様である結果となった。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410282679547202050","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000259322807"}],"foaf:name":[{"@language":"en","@value":"Fujii Masato"},{"@language":"ja","@value":"藤井 正人"}],"jpcoar:affiliationName":[{"@language":"en","@value":"National Institute of Sensory Organs, National Hospital Organization,Tokyo Medical Center"},{"@language":"ja","@value":"国立病院機構東京医療センター"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13495747"},{"@type":"EISSN","@value":"18818382"},{"@type":"NCID","@value":"AA11985555"}],"prism:publicationName":[{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"},{"@language":"en","@value":"Toukeibu Gan"},{"@language":"ja","@value":"頭頸部癌"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Head and Neck Cancer"},{"@language":"ja","@value":"日本頭頸部癌学会"}],"prism:publicationDate":"2012","prism:volume":"38","prism:number":"4","prism:startingPage":"390","prism:endingPage":"393"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2013118478"}],"availableAt":"2012","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Oropharynx%20cancer","dc:title":"Oropharynx cancer"},{"@id":"https://cir.nii.ac.jp/all?q=Human%20papilloma%20virus","dc:title":"Human papilloma virus"},{"@id":"https://cir.nii.ac.jp/all?q=Multicenter%20trial","dc:title":"Multicenter trial"},{"@id":"https://cir.nii.ac.jp/all?q=%E4%B8%AD%E5%92%BD%E9%A0%AD%E7%99%8C","dc:title":"中咽頭癌"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%83%92%E3%83%88%E4%B9%B3%E9%A0%AD%E8%85%AB%E3%82%A6%E3%82%A4%E3%83%AB%E3%82%B9","dc:title":"ヒト乳頭腫ウイルス"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%A4%9A%E6%96%BD%E8%A8%AD%E5%85%B1%E5%90%8C%E7%A0%94%E7%A9%B6","dc:title":"多施設共同研究"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1361699994798182656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma?"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749397983232","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden : an epidemic of viral-induced carcinoma?"}]},{"@id":"https://cir.nii.ac.jp/crid/1570854174328121216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evidence for a causal association between human papillomavirus and a subset of head and neck cancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649304833152","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135649304834176","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449118512000","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Case-control study of human papillomavirus and oropharyngeal cancer"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1001353027"},{"@type":"CROSSREF","@value":"10.5981/jjhnc.38.390"},{"@type":"CIA","@value":"10031170543"}]}