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Lack of Association of Genetic Polymorphisms in the Interleukin-1 .BETA., Interleukin-1 Receptor Antagonist, Interleukin-4, and Interleukin-10 Genes With Risk of Rheumatic Heart Disease in Taiwan Chinese
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- Chou Hsiang-Tai
- Division of Cardiology, Department of Medicine, China Medical University Hospital
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- Tsai Chang-Hai
- Taichung Healthcare and Management University
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- Chen Wei-Cheng
- Department of Pediatrics, Medical Research and Medical Genetics, China Medical University Hospital
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- Tsai Fuu-Jen
- Department of Pediatrics, Medical Research and Medical Genetics, China Medical University Hospital College of Chinese Medicine, China Medical University
Bibliographic Information
- Published
- 2005
- Resource Type
- journal article
- DOI
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- 10.1536/ihj.46.397
- Publisher
- International Heart Journal Association
Search this article
Description
Inflammation and genetics may play a role in the pathogenesis of rheumatic heart disease (RHD). The aim of this study was to test whether interleukin (IL)-1β, IL-1 receptor antagonist (IL-1Ra), IL-4, or IL-10 gene polymorphisms could be used as markers of susceptibility to or severity of RHD among the Chinese population in Taiwan.<br> A group of 115 patients with RHD diagnosed by echocardiography, and 163 age- and sex-matched normal control subjects were studied. IL-1β promoter, IL-1β exon 5, IL-1Ra, IL-4 promoter, IL-4 intron 3, and IL-10 gene polymorphisms were identified by polymerase chain reaction-based restriction analysis.<br> There was no significant difference in the distribution of genotypes and allelic frequencies between RHD cases and controls for IL-1β promoter, IL-1β exon 5, IL-1Ra, IL-4 promoter, IL-4 intron 3, and IL-10 gene polymorphisms. Further categorization of the RHD patients into mitral valve disease and combined valve disease subgroups also revealed no statistical difference in these gene polymorphisms when compared with controls.<br> These findings suggest that the IL-1β, IL-1Ra, IL-4, or IL-10 gene polymorphisms are not suitable genetic markers for RHD in Taiwan Chinese.<br>
Journal
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- International Heart Journal
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International Heart Journal 46 (3), 397-406, 2005
International Heart Journal Association