Effects of Ultrasound on Bone Formation Induced by BMP-2

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  • YAMAJI Kozo
    Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • NISHIMURA Maiko
    Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • NISHITANI Yoshihiro
    Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • IZAWA Shunji
    Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • HOSHIKA Tomohiro
    Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • SHIODE Shintaro
    Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • YOSHIYAMA Masahiro
    Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Abstract

Low-intensity pulsed ultrasound (LIPUS) is therapeutic instrument of improving bone healing, and Bone Morphogenetic Protein-2 (BMP-2) has been demonstrated to enhance bone formation. The present study was designed to evaluate the effects of LIPUS on bone formation induced by BMP-2 at palatal subperiosteal sites in Wister rats. Alginated gel (AG) contained BMP-2 (1.0µg/µL) was implanted into the palatal left site (BMP site), and AG alone was the right site (AG site). The rats were divided into two groups; LIPUS group, ultrasound (1MHz, 160mW, 5 min) was performed every three days, and non-LIPUS group. At 3 weeks after surgery, thickness of new bone of BMP site was significantly higher than that of AG site (P<0.05). Newly formed bone of BMP site was continuous with the original bone at non-LIPUS group, whereas it was almost integrated with the original bone at LIPUS group.<br>These results suggest that LIPUS has the ability to enhance the maturation of newly formed bone induced by BMP-2.

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