{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205226593664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1536/ihj.14-034"}},{"identifier":{"@type":"PMID","@value":"25310932"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/ihj/55/6/55_14-034/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004694361"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2015215313"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Effects of the T/L-type Calcium Channel Blocker Benidipine on Albuminuria and Plasma Aldosterone Concentration"}],"dcterms:alternative":[{"@language":"en","@value":"A Pilot Study Involving Switching from L-type Calcium Channel Blockers to Benidipine"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Albuminuria and a high plasma aldosterone concentration (PAC) are prognosis factors predicting a poor outcome for cardiovascular disease. We examined here the effects of benidipine, a T/L-type calcium channel blocker (CCB), on albuminuria and PAC.<br>Thirty-one patients with essential hypertension who received an L-type CCB and achieved the target blood pressure (BP) indicated by the Treatment Guidelines of the Japan Society of Hypertension (JSH2009) were investigated. The Ltype CCB under treatment was switched to benidipine at a dose in which equivalent BP reduction was expected. BP and estimated glomerular filtration rate at 6 months after switching to benidipine were not significantly different from those at baseline. The urinary-albumin-creatinine ratio (UACR) decreased significantly by 36.9% (<i>P</i> = 0.001). No significant change was observed in plasma renin activity (<i>P</i> = 0.063). The PAC of all patients decreased significantly by 11.8% (<i>P</i> = 0.002). When analyzed by daily doses of benidipine, the PAC appeared to have decreased in patients who received 4 mg per day of benidipine (<i>n</i> = 14), although statistical significance was not reached (<i>P</i> = 0.096). The PAC in patients who received 8 mg per day of benidipine (<i>n</i> =17) was significantly reduced by 13.2% (<i>P</i> = 0.017).<br>In hypertensive patients whose BP is controlled by L-type CCB, switching to the T/L-type CCB benidipine maintained BP control and reduced UACR. In addition, the high dose of benidipine reduced the PAC independent of BP control. These results suggest the T/L-type CCB benidipine may contribute to cardio-renal protection in addition to lowering BP."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801207374080","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30451347"},{"@type":"NRID","@value":"1000030451347"},{"@type":"NRID","@value":"9000004079305"},{"@type":"NRID","@value":"9000291602600"},{"@type":"NRID","@value":"9000367428931"},{"@type":"NRID","@value":"9000347297635"},{"@type":"NRID","@value":"9000240094070"},{"@type":"NRID","@value":"9000412276707"},{"@type":"NRID","@value":"9000283578987"},{"@type":"NRID","@value":"9000257808454"},{"@type":"NRID","@value":"9000410462635"},{"@type":"NRID","@value":"9000021167034"},{"@type":"NRID","@value":"9000021483924"},{"@type":"NRID","@value":"9000021149375"},{"@type":"NRID","@value":"9000397685473"},{"@type":"NRID","@value":"9000265248805"},{"@type":"NRID","@value":"9000021327552"},{"@type":"NRID","@value":"9000262357174"},{"@type":"NRID","@value":"9000004135985"},{"@type":"NRID","@value":"9000020582574"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0122645"}],"foaf:name":[{"@language":"en","@value":"Tani Shigemasa"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Cardiology, Surugadai Nihon University Hospital"},{"@language":"en","@value":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801195932672","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30287627"},{"@type":"NRID","@value":"1000030287627"},{"@type":"NRID","@value":"9000240095900"},{"@type":"NRID","@value":"9000256092947"},{"@type":"NRID","@value":"9000001696634"},{"@type":"NRID","@value":"9000317155260"},{"@type":"NRID","@value":"9000258237128"},{"@type":"NRID","@value":"9000290821434"},{"@type":"NRID","@value":"9000347297638"},{"@type":"NRID","@value":"9000283578990"},{"@type":"NRID","@value":"9000256071338"},{"@type":"NRID","@value":"9000410462639"},{"@type":"NRID","@value":"9000001842237"},{"@type":"NRID","@value":"9000408997803"},{"@type":"NRID","@value":"9000242092928"},{"@type":"NRID","@value":"9000403424857"},{"@type":"NRID","@value":"9000004088840"},{"@type":"NRID","@value":"9000265248806"},{"@type":"NRID","@value":"9000256092599"},{"@type":"NRID","@value":"9000405643690"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0049867"}],"foaf:name":[{"@language":"en","@value":"Takahashi 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Atsushi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Cardiology, Department of Medicine, Nihon University School of Medicine"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13492365"},{"@type":"LISSN","@value":"13492365"},{"@type":"EISSN","@value":"13493299"}],"prism:publicationName":[{"@language":"en","@value":"International Heart Journal"},{"@language":"en","@value":"Int. Heart J."}],"dc:publisher":[{"@language":"en","@value":"International Heart Journal Association"},{"@language":"ja","@value":"一般社団法人 インターナショナル・ハート・ジャーナル刊行会"}],"prism:publicationDate":"2014","prism:volume":"55","prism:number":"6","prism:startingPage":"519","prism:endingPage":"525"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/ihj/55/6/55_14-034/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2015215313"}],"availableAt":"2014","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cardio-renal%20interaction","dc:title":"Cardio-renal interaction"},{"@id":"https://cir.nii.ac.jp/all?q=Hypertension","dc:title":"Hypertension"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050013397240361344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Calcium channel blocker in patients with chronic kidney 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Heart Failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994694588928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Review of aldosterone- and angiotensin II-induced target organ damage and prevention"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995400467456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Treatment of Coronary Spastic Angina With a Statin in Addition to a Calcium Channel Blocker: A Pilot Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996266076416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distinct functions of T- and L-type calcium channels during activation of bovine adrenal glomerulosa cells."}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469219051776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Therapeutic perspectives in hypertension: novel means for renin-angiotensin-aldosterone system modulation and emerging 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hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419471191808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Azelnidipine Reduces Urinary Protein Excretion and Urinary Liver-Type Fatty Acid Binding Protein in Patients with Hypertensive Chronic Kidney Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893998582144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896069404288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pretreatment Plasma Renin Activity Levels Correlate With the Blood Pressure Response to Telmisartan in Essential 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