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Left Atrial Dyssynchrony in Patients With Nonobstructive Hypertrophic Cardiomyopathy Evaluated by Myocardial Strain Imaging
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- Kawanishi Yasunori
- Third Department of Internal Medicine, Osaka Medical College
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- Ito Takahide
- Third Department of Internal Medicine, Osaka Medical College
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- Futai Rie
- Third Department of Internal Medicine, Osaka Medical College
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- Iimori Akio
- Third Department of Internal Medicine, Osaka Medical College
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- Ukimura Akira
- Third Department of Internal Medicine, Osaka Medical College
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- Sohmiya Koichi
- Third Department of Internal Medicine, Osaka Medical College
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- Terasaki Fumio
- Third Department of Internal Medicine, Osaka Medical College
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- Suwa Michihiro
- Department of Cardiovascular Medicine, Hokusetsu General Hospital
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- Kitaura Yasushi
- Third Department of Internal Medicine, Osaka Medical College
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Description
Background. The present study was conducted to examine left atrial (LA) dyssynchrony, determined by echocardiographic myocardial strain imaging, in patients with hypertrophic cardiomyopathy (HCM).<br> Methods. We studied 26 patients with HCM (20 men and 6 women, age, 66±7 years) and 25 normal subjects (controls). Tissue Doppler-based strain images were recorded in the apical 2-, 4-chamber, and long-axis views. The LA strain curve was obtained with the region of interest placed at the 5 LA segments, namely, the atrial septum, lateral wall, inferior wall, anterior wall, and posterior wall. We measured standard deviation (SD) of the time-periods between aortic valve opening and maximal strain (reservoir dyssynchrony index) and SD of the time-periods between mitral valve opening and minimal strain (emptying dyssynchrony index).<br>Results. Compared with controls, patients with HCM had greater indexes of reservoir (40±23 ms vs. 23±8 ms, p=0.001) and emptying (37±17 ms vs. 28±11 ms, p=0.02) dyssynchrony. Reservoir dyssynchrony (index >39 ms) was detectable in 11 patients, and emptying dyssynchrony (index >50 ms) was detectable in 5 patients. Patients with reservoir dyssynchrony had a greater LV mass index than those without (182±45 g/m2 vs. 142±32 g/m2, p=0.01), whereas patients with emptying dyssynchrony had greater LA minimal volume (39±12 ml/m2 vs. 26±10 ml/m2 p=0.02) and lower LA emptying fraction than those without (27±3% vs. 39±11%, p=0.02).<br>Conclusions. LA dyssynchrony can be present throughout the cardiac cycle in patients with HCM. LA dyssynchrony is more common in the reservoir phase and may be attributed to significant myocardial involvement.
Journal
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- Journal of Echocardiography
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Journal of Echocardiography 6 (2), 46-53, 2008
Japanese Society of Echocardiography
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Details 詳細情報について
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- CRID
- 1390001205232561792
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- NII Article ID
- 130004471077
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- ISSN
- 1880344X
- 13490222
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed
