The effects of mushroom chitosan on antiobesity in an animal obesity model

DOI 22 References

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Other Title
  • 肥満モデル動物におけるキノコキトサンの抗肥満効果
  • ヒマン モデル ドウブツ ニ オケル キノコキトサン ノ コウヒマン コウカ

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Abstract

Chitosan is a polysaccharide produced by deacetylation of chitin in mushroom cell walls and exoskeletons of crustaceans. In this study, we examined the effects of mushroom chitosan (chitosan made from Flammulina velutipes) on hyperlipidemia and obesity in an animal obesity model comprising Zucker fatty rats. Mushroom chitosan administered to Zucker fatty rat groups led to a significant reduction in body weight, as well as a decrease of lipid accumulation in liver and an increased lipid excretion rate in feces. Triglyceride, total cholesterol and LDL-cholesterol levels decreased significantly as shown by blood biochemical testing. Mushroom chitosan also led to improvement of blood lipid metabolism and inhibition of lipid accumulation in the liver. The mechanism of these effects involved both inhibition of lipid absorption from the intestine and lipolysis in adipose cells. Our results suggest that mushroom chitosan is effective for reducing the risk of both obesity and metabolic syndrome.

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Details

  • CRID
    1390001205288203776
  • NII Article ID
    110009604525
  • NII Book ID
    AA12415767
  • DOI
    10.24465/msb.21.1_30
  • ISSN
    24327069
    13487388
  • NDL BIB ID
    024749650
  • Text Lang
    ja
  • Data Source
    • JaLC
    • NDL
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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