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Vesicular Glutamate Transporter 2 Expression in the Rat Pineal Gland: Detailed Analysis of Expression Pattern and Regulatory Mechanism
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- YOSHIDA Sachine
- Kuroda Research Unit for Affiliative Social Behavior, RIKEN Brain Science Institute Laboratory of Neuroendocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- HISANO Setsuji
- Laboratory of Neuroendocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Description
Melatonin, a hormone secreted by the pineal gland, is closely related physiologically to circadian rhythm, sleep and reproduction, and also psychiatrically to mood disorders in humans. Under circadian control, melatonin secretion is modulated via nocturnal autonomic (adrenergic) stimulation to the gland, which expresses vesicular glutamate transporter (VGLUT) 1, VGLUT2 and a VGLUT1 splice variant (VGLUT1v), glutamatergic markers. Expression of VGLUT2 gene and protein in the intact gland has been reported to exhibit a rhythmic change during a day. To study VGLUT2 expression is under adrenergic control, we here performed an in vitro experiment using dispersed pineal cells of rats. Stimulation of either β-adrenergic receptor or cAMP production to the pineal cells was shown to increase mRNA level of VGLUT2, but not VGLUT1 and VGLUT1v. Because an ability of glutamate to inhibit melatonin production was previously reported in the cultured gland, it is likely that pineal VGLUT2 transports glutamate engaged in the inhibition of melatonin production.
Journal
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- Kansei Engineering International Journal
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Kansei Engineering International Journal 11 133-137, 2012
Japan Society of Kansei Engineering
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Details 詳細情報について
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- CRID
- 1390001205325452288
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- NII Article ID
- 130002148649
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- BIBCODE
- 2012KEIJ...11..133Y
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- ISSN
- 21857865
- 18840841
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed
