{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205337293440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.7792/jlspm.7.121"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"026831289"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/026831289"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I026831289"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jlspm/7/3/7_121/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005107020"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2016151747"}}],"dc:title":[{"@language":"ja","@value":"透析患者の足病変が起こる理由とその予防対策"},{"@language":"en","@value":"The pathogenesis and therapeutic strategy for foot lesions in patients undergoing renal replacement therapy"},{"@language":"ja-Kana","@value":"トウセキ カンジャ ノ アシ ビョウヘン ガ オコル リユウ ト ソノ ヨボウ タイサク"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Foot lesions are an important problem in patients undergoing renal replacement therapy（RRT）. The main cause of foot lesions in these patients is peripheral artery disease（PAD）. The prevalence of PAD among patients with end-stage renal disease is significantly higher than that of the general population. RRT patients with PAD show high mortality due to cardiovascular disease. Thus, PAD is an important issue in end-stage renal disease patients. Several risk factors of PAD have been identified in ESRD patients. Diabetes mellitus and smoking are the most significant risk factors. Other factors, including male sex, hyperlipidemia, hypertension, and infection are also important risk factors. In dialysis patients, significant risk factors include hyperlipidemia and hypercalcemia. The use of aggressive blood purification and non-calcemic phosphate binder are recommended. Dialysis patients with PAD often lack symptoms, such as intermittent claudication. Critical limb ischemia（CLI）resistant to treatment is occasionally an initial PAD finding. Therefore, early diagnosis, early treatment, and prophylaxis, are very important in PAD patients undergoing RRT."},{"@language":"ja","@value":"透析患者における足病変は末梢動脈疾患（PAD）が原因となることが多い．透析患者のPAD罹患率は一般人口と比較して高いとされ，PADを合併した透析患者は非合併透析患者に比し，生命予後は著明に悪化し，PADが透析患者の重大な予後規定因子であるといえる．しかしながら，透析患者のPADは間欠性跛行などの症状に乏しく進行した重症虚血肢（critical limb ischemia:CLI）で発見されることも少なくない．このため，透析患者においてPADは発症病態を理解したうえでの，予防対策や早期発見，早期治療が重要となる．それには，糖尿病患者における血糖コントロール，足清潔保持，感染対策，フットケアなどに加え，禁煙，高脂血症対策，透析療法に伴う高リン血症のコントロールと薬物療法が重要となる．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001205337293441","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000309576723"}],"foaf:name":[{"@language":"ja","@value":"岩谷 由佳"},{"@language":"en","@value":"Iwatani Yuka"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Nephrology, Department of Internal Medicine, Wakayama Medical University"},{"@language":"ja","@value":"和歌山県立医科大学腎臓内科学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801194661248","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20208284"},{"@type":"NRID","@value":"1000020208284"},{"@type":"NRID","@value":"9000345249777"},{"@type":"NRID","@value":"9000363349199"},{"@type":"NRID","@value":"9000290128283"},{"@type":"NRID","@value":"9000254508464"},{"@type":"NRID","@value":"9000254095356"},{"@type":"NRID","@value":"9000383070295"},{"@type":"NRID","@value":"9000254512696"},{"@type":"NRID","@value":"9000309576724"},{"@type":"NRID","@value":"9000254505254"},{"@type":"NRID","@value":"9000254506902"},{"@type":"NRID","@value":"9000254094177"},{"@type":"NRID","@value":"9000363910010"},{"@type":"NRID","@value":"9000345197759"}],"foaf:name":[{"@language":"ja","@value":"根木 茂雄"},{"@language":"en","@value":"Negi Shigeo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Nephrology, Department of Internal Medicine, Wakayama Medical University"},{"@language":"ja","@value":"和歌山県立医科大学腎臓内科学講座"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205337293442","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000309576725"}],"foaf:name":[{"@language":"ja","@value":"新屋 智珠子"},{"@language":"en","@value":"Shinya Chizuko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Dialysis Center, Kodama Hospital, Medical Corporation Hakubun-Kai"},{"@language":"ja","@value":"医療法人博文会児玉病院"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205337293443","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000309576726"}],"foaf:name":[{"@language":"ja","@value":"児玉 直也"},{"@language":"en","@value":"Kodama Naoya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Dialysis Center, Kodama Hospital, Medical Corporation 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隆"},{"@language":"en","@value":"Shigematsu Takashi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Nephrology, Department of Internal Medicine, Wakayama Medical University"},{"@language":"ja","@value":"和歌山県立医科大学腎臓内科学講座"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1883857X"},{"@type":"LISSN","@value":"1883857X"},{"@type":"EISSN","@value":"21871957"},{"@type":"NDL_BIB_ID","@value":"000010067881"},{"@type":"ISSN","@value":"1883857X"},{"@type":"NCID","@value":"AA12678449"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of Japanese Society of Limb Salvage and Podiatric Medicine"},{"@value":"日本下肢救済・足病学会誌"},{"@language":"en","@value":"J Jpn Soc Limb Salvage Podiatr Med"},{"@language":"ja","@value":"日本下肢救済・足病学会誌"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Limb Salvage and Podiatric 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