Attenuating effects of clenbuterol, β<sub>2</sub>-agonist, on immobilization - induced atrophy of rat hindlimb muscle fibers

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  • Suzuki Hideki
    Department of Health and Physical Education, Aichi University of Education
  • Kitaura Takashi
    Laboratory of Exercise Biochemistry, Division of Sports Education, Health Service Center, Kanazawa University

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  • Attenuating effects of clenbuterol, β₂-agonist, on immobilization : induced atrophy of rat hindlimb muscle fibers

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In this review, we discuss the morphologic influence of clenbuterol on muscle atrophy with particular focus on cast-immobilization used in surgical care. β2-agonists induce muscle hypertrophy, particularly in fast muscles. Similar to these anabolic actions, the β2-agonist clenbuterol attenuates immobilization-induced atrophy in fast muscles. Furthermore, the attenuating effects of this agonist on muscle atrophy may be related to its preventative effect in fast muscle fibers.

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