アルキル化剤のマウスに対する染色体異状活発性と胎仔毒性との関連-1-Methyl methane-sulfonateのカフェインによる胎仔致死作用の軽減(速報)〔英文〕

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  • Studies on the relation between alkylating agents-induced chromosomal aberrations and their embryotoxicities in mice. I. The reduction of the embryolethality of methyl methanesulfonate by caffeine.
  • アルキルカザイ ノ マウス ニ タイスル センショクタイ イジョウ カッパツセ
  • I. The reduction of the embryolethality of methyl methanesulfonate by caffeine

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Effects of caffeine on methyl methanesulfonate (MMS)-induced embryolethality and chromosomal aberrations in hepatocytes of mouse embryos were examined. MMS was given intraperitoneally but caffeine subcutaneously on day 12 of gestation. Embryolethality was checked on day 18 of gestation but chromosomal aberrations at 3, 6, 12, 18, 24, 36 and 48 hours after administration of drugs. The dose of MMS was chosen, which caused severe embryolethality but not any observed chromosomal aberrations. The simultaneous administration of caffeine reduced the embryolethality of MMS while the frequency of chromosomal aberrations increased significantly. The reduction of the embryolethality of MMS may be ascribe to the toxic effects of MMS which must be antagonized by caffeine.

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