{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205473398144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1266/ggs.82.89"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DC%2BD2s7ptlKnsg%3D%3D"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"8804598"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/8804598"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I8804598"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/ggs/82/1/82_1_89/_pdf"}},{"identifier":{"@type":"NAID","@value":"10024393897"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2007220941"}}],"dc:title":[{"@language":"en","@value":"Molecular Phylogenetic Analysis of the Human Endogenous Retrovirus E (HERV-E) Family in Human Tissues and Human Cancers"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The human genome is estimated to contain up to 50 copies of full-length and truncated members of HERV-E family. They are thought to be involved in human gene transcription. Here we examine the expression pattern and phylogenetic relationships of the HERV-E in diverse human tissues and cancer cells using RT-PCR amplification and bioinformatic tools. The <i>env</i> gene was expressed in many human tissues (brain, prostate, testis, kidney, placenta, spleen, thymus and uterus) but not in heart, liver, lung and skeletal muscle, importantly, HERV-E expression was detected in all cancer cell lines examined (RT4, PFSK-1, BT-474, HCT-116, TE-1, UO-31, Jurkat, HepG2, A549, MCF7, OVCAR-3, MIA-PaCa-2, PC3, LOX-IMVI, AZ521, 2F7, U-937 and C-33A), suggesting that HERV-E family are expressed corresponding to the transcriptional program of human tissues and human cancer cells. Phylogenetic analysis of HERV-E <i>env</i> family from human tissues, cancer cells and our previous data identify two groups (I and II) through evolutionary divergence. Taken together, HERV-E family expression in human tissues and human cancer cells exhibited close relationships of the <i>env</i> gene sequences across human chromosomes. These active HERV-E elements deserve further investigation as potential pathogenic factors in human diseases such as cancers.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001205473398145","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014215207"}],"foaf:name":[{"@language":"en","@value":"Kim Heui-Soo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Biological Sciences, College of Natural Sciences, Pusan National University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205473398144","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014215204"}],"foaf:name":[{"@language":"en","@value":"Yi Joo-Mi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Biological Sciences, College of Natural Sciences, Pusan National University"},{"@language":"en","@value":"Cancer Biology division, The Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13417568"},{"@type":"LISSN","@value":"13417568"},{"@type":"EISSN","@value":"18805779"},{"@type":"NDL_BIB_ID","@value":"000000156883"},{"@type":"ISSN","@value":"13417568"},{"@type":"NCID","@value":"AA11077421"}],"prism:publicationName":[{"@language":"en","@value":"Genes & Genetic Systems"},{"@language":"en","@value":"Genes Genet. Syst."}],"dc:publisher":[{"@language":"en","@value":"The Genetics Society of Japan"},{"@language":"ja","@value":"日本遺伝学会"}],"prism:publicationDate":"2007","prism:volume":"82","prism:number":"1","prism:startingPage":"89","prism:endingPage":"98"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/8804598"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I8804598"},{"@id":"http://www.jstage.jst.go.jp/article/ggs/82/1/82_1_89/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2007220941"}],"availableAt":"2007","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=evolution","dc:title":"evolution"},{"@id":"https://cir.nii.ac.jp/all?q=human%20endogenous%20retrovirus%20E%20(HERV-E)","dc:title":"human endogenous retrovirus E (HERV-E)"},{"@id":"https://cir.nii.ac.jp/all?q=cancer%20cell","dc:title":"cancer cell"},{"@id":"https://cir.nii.ac.jp/all?q=human%20tissues","dc:title":"human tissues"},{"@id":"https://cir.nii.ac.jp/all?q=phylogeny","dc:title":"phylogeny"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011142937824256","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Initial sequencing and analysis of the human genome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143613299584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular cloning and phylogeny of HERV-E family that is expressed in Japanese monkey (Macaca fuscata) tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144415695872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Influence of the human endogenous retrovirus-like element HERV-E.PTN on the expression of growth factor pleiotrophin: a critical role of a retroviral Sp1-binding site"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146398197248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detecting the expression of human endogenous retrovirus E <i>envelope</i> transcripts in human prostate adenocarcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146451319680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Endogenous Proviruses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620775615232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Retroviruses and primate evolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092894613120","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569287540992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Analysis of the Endogenous Retroviral Promoter of the Human Endothelin B Receptor Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570127797504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differences in HERV-K LTR insertions in orthologous loci of humans and great apes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571438149248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative Analyses of LTRs of the ERV-H Family of Primate-Specific Retrovirus-like Elements Isolated from Marmoset, African Green Monkey, and Man"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043871970560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The pathogenic potential of endogenous retroviruses: facts and fantasies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044272979456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The full-length envelope of an HERV-H 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Human Genome Mapping Project Database"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844904036864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of Human Endogenous Retrovirus HC2-Like Elements in Primates"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318570843904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Search for active endogenous retroviruses: identification and characterization of a HERV-E gene that is expressed in the pancreas and thyroid"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319417756800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation and phylogeny of endogenous retrovirus sequences belonging to the HERV-W family in primates"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319740357376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HERV-F(XA34) is a full-length human endogenous retrovirus expressed in placental and fetal tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321005576192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of the human endogenous retrovirus HERV-W family in various human tissues and cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796204022912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of an endogenous retroviral gene product in human placenta"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268615043584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long terminal repeats of human endogenous retrovirus K family (HERV‐K) specifically bind host cell nuclear proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268740384768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure and Phylogenetic Analysis of an Endogenous Retrovirus Inserted into the Human Growth Factor Gene Pleiotrophin"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270982328192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences"}]},{"@id":"https://cir.nii.ac.jp/crid/1523106604584480768","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"Search for active endogenous retroviruses: identification and characterization of a HERV-E gene that is expressed in the pancreas and thyroid"},{"@language":"ja-Kana","@value":"Search for active endogenous retroviruses identification and characterization of a HERV E gene that is expressed in the pancreas and thyroid"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750783016448","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"MEGA2 : molecular evolutionary genetics analysis software"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009750783018752","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of endogenous retroviruses, ERV3 and lambda 4-1, in synovial tissues from patients with rheumatoid arthritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009751803462528","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"HERV-F (XA34) is a full-length human endogenous retrovirus expressed in placental and fetal tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1570291225759730432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The pathogenic potential of endogenous retroviruses : facts and fantasies"}]},{"@id":"https://cir.nii.ac.jp/crid/1570572700857979904","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The viruses in all of us : characteristics and biological significance of human 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HERV-E. PTN on the expression of growth factor pleiotrophin : a critical role of a retroviral Sp1-binding site"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125782975360","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative analyses of LTRs of the ERV-H family of primate-specific retrovirus-like elements isolated from marmoset, African green monkey, and man"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417126435636352","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences"}]},{"@id":"https://cir.nii.ac.jp/crid/1571698600643281280","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Survey of human genes of retroviral origin : identification and transcriptome of the genes with coding capacity for complete envelope 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brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105976547541376","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Structure and phylogenetic analysis of an endogenous retrovirus inserted into the human growth factor gene pleiotrophin"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450503544704","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular cloning and phylogeny of HERV-E family that is expressed in Japanese monkey (Macaca fuscata) tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450503545984","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Human endogenous proviruses"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387450503547136","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Repbase update : a database and an electronic journal of repetitive 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