Long-term Evaluation of Caries Inhibition Effect Using Fluoride-containing Materials

DOI 45 References
  • KOJIMA Kentaro
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • KOMATSU Hisanori
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • FUNATO Yoshiki
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • KIJIMURA Taiki
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • MATSUDA Yasuhiro
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • OKUYAMA Katsushi
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
  • SANO Hidehiko
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine

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  • フッ化物含有材料におけるう蝕抑制効果の長期的評価

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The long-term caries inhibition effect of fluoride-containing materials (FCMs) is still a matter of debate, since the amount of fluoride released from FCM decreases with time. The purpose of this study was to evaluate the long-term caries inhibition effect of FCMs aged for 1.5 years by means of pH-cycling. Two glass ionomer cements (Fuji IXGP Extra (EX) and Fuji IXGP Fast Capsule (FF)), a combination of F-containing resin (Unifil-flow) and non-F adhesive (G-bond) (UG), and a combination of non-F resin (Clearfil AP-X) and F-containing adhesive (Clearfil Mega Bond FA) (AF) were used as FCMs in this study. A combination of non-F resin (Solare) and non-F adhesive (Clearfil Mega Bond) (SM) was used as a control. Each material was filled into a cavity on the buccal surface of a human premolar. Samples were stored in distilled water for 24 hours (short-time group: ST) or 1.5 years (long-time group: LT) except for SM. After storing, a 150 μm-thick single-section specimen was prepared, and then was subjected to the pH-cycling system (pH 4.5-7.0), in which six cycles were carried out per day for five weeks. A transverse micro radiography (TMR) image of each specimen was taken after 1, 3, or 5 weeks of pH-cycling and caries inhibition effect was analyzed quantitatively by integrated mineral loss (IML). The results were as follows. For the ST group, three of the FCMs (EX, FF and UG) indicated significantly lower IML compared with the control and showed caries inhibition effect by the remineralization with fluoride uptake in the adjacent cavity margin (EX>FF>UG). However, there was no significant difference in AF. For the LT group, there was no difference in IML among the FCMs and there was no difference in the caries inhibition effect which was observed in the ST group among all materials. For both the ST and LT groups, there was no caries inhibition effect by fluoride uptake in the cavity wall.

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