Familial Repetitive Furunculosis due to Community-associated Methicillin-resistant <i>Staphylococcus aureus</i>

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  • Matsuura Midori
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine
  • Inomata Naoko
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine
  • Fujita Hiroyuki
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine
  • Nozaki Yuu
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine
  • Wan Tsai-Wen
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine International Medical Education and Research Center
  • Hung Wei-Chun
    International Medical Education and Research Center Department of Microbiology and Immunology, Kaohsiung Medical University
  • Yamasaki Osamu
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry
  • Yamamoto Tatsuo
    International Medical Education and Research Center
  • Iwatsuki Keiji
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry
  • Aihara Michiko
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine

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Other Title
  • 家族内発症した市中型MRSAによる癤腫症の4例
  • カゾク ナイ ハッショウ シタ シ チュウガタ MRSA ニ ヨル セツシュショウ ノ 4レイ

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Description

We report a familial case of repetitive furunculosis due to Community-associated MRSA (CA-MRSA), disseminating from a male case to his wife, his son and his mother-in-law. Screening of samples from furuncles of the four cases showed methicillin-resistant Staphylococcus aureus (MRSA). The results of PCR showed that all the isolates showed an identical antimicrobial susceptibility profile, carried type V SCCmec, and harbored the pvl gene. In addition, the clonal relationship determined by pulsed field gel electrophoresis using Sma I enzyme for genomic DNA digestion showed that isolates from all four cases displayed indistinguishable electrophoretic patterns. The cases were diagnosed as repetitive furunculosis due to CA-MRSA on the basis of the drug sensitivity pattern of MRSA isolated from the four cases and the positivity to Panton-Valentine leukocidine (PVL). In the two cases with atopic dermatitis, furunculosis due to CA-MRSA recurred despite long-term oral administration of trimethoprim-sulfamethoxazole.

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