Optimum Preparation of Levocarnitine Chloride Solution in the Hospital Pharmacy

  • TANAKA Hiroaki
    Department of Pharmacy, Kagawa University Hospital Department of Microbiology, Faculty of Medicine, Kagawa University
  • ASAKURA Masato
    Department of Pharmacy, Kagawa University Hospital
  • DOI Chiaki
    Department of Pharmacy, Kagawa University Hospital
  • FUKUOKA Noriyasu
    Department of Pharmacy, Kagawa University Hospital
  • TAMAI Eiji
    Department of Microbiology, Faculty of Medicine, Kagawa University
  • MIYATA Shigeru
    Department of Microbiology, Faculty of Medicine, Kagawa University
  • MATSUSHITA Osamu
    Department of Microbiology, Faculty of Medicine, Kagawa University
  • OKABE Akinobu
    Department of Microbiology, Faculty of Medicine, Kagawa University
  • NEGAYAMA Kiyoshi
    Department of Clinical Laboratory, Kagawa University Hospital
  • HOUCHI Hitoshi
    Department of Pharmacy, Kagawa University Hospital

Bibliographic Information

Other Title
  • 院内製剤塩化レボカルニチン懸濁液の最適な調製法について
  • インナイ セイザイ エンカ レボカルニチン ケンダクエキ ノ サイテキ ナ チョウセイホウ ニ ツイテ

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Description

  Levocarnitine chloride is used for the therapeutic purpose of levocarnitine deficiency. For infants, however, levocarnitine chloride tablets must be crushed to avoid difficulties associated with swallowing, and also to administer an appropriately low dosage. Since the tablet is extremely hygroscopic and sour, it is dissolved in water containing simple syrup after crushing. In this study we investigated the stability of the drug after dissolution to optimize its preparation for clinical use. It was shown to be stable for at least 90 days after preparation, and microbes did not grow in 1—10% (w/v) solutions (pH 2.0—2.5) regardless of the presence or absence of simple syrup. Furthermore, the autoclaved levocarnitine chloride solution was as stable as the non-autoclaved one. In conclusion, the method employed in our hospital for the preparation of levocarnitine chloride for infants is appropriate and is recommended as a standard medicine supply method among different facilities.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 126 (9), 805-809, 2006-09-01

    The Pharmaceutical Society of Japan

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