Optimum Preparation of Levocarnitine Chloride Solution in the Hospital Pharmacy
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- TANAKA Hiroaki
- Department of Pharmacy, Kagawa University Hospital Department of Microbiology, Faculty of Medicine, Kagawa University
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- ASAKURA Masato
- Department of Pharmacy, Kagawa University Hospital
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- DOI Chiaki
- Department of Pharmacy, Kagawa University Hospital
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- FUKUOKA Noriyasu
- Department of Pharmacy, Kagawa University Hospital
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- TAMAI Eiji
- Department of Microbiology, Faculty of Medicine, Kagawa University
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- MIYATA Shigeru
- Department of Microbiology, Faculty of Medicine, Kagawa University
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- MATSUSHITA Osamu
- Department of Microbiology, Faculty of Medicine, Kagawa University
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- OKABE Akinobu
- Department of Microbiology, Faculty of Medicine, Kagawa University
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- NEGAYAMA Kiyoshi
- Department of Clinical Laboratory, Kagawa University Hospital
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- HOUCHI Hitoshi
- Department of Pharmacy, Kagawa University Hospital
Bibliographic Information
- Other Title
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- 院内製剤塩化レボカルニチン懸濁液の最適な調製法について
- インナイ セイザイ エンカ レボカルニチン ケンダクエキ ノ サイテキ ナ チョウセイホウ ニ ツイテ
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Description
Levocarnitine chloride is used for the therapeutic purpose of levocarnitine deficiency. For infants, however, levocarnitine chloride tablets must be crushed to avoid difficulties associated with swallowing, and also to administer an appropriately low dosage. Since the tablet is extremely hygroscopic and sour, it is dissolved in water containing simple syrup after crushing. In this study we investigated the stability of the drug after dissolution to optimize its preparation for clinical use. It was shown to be stable for at least 90 days after preparation, and microbes did not grow in 1—10% (w/v) solutions (pH 2.0—2.5) regardless of the presence or absence of simple syrup. Furthermore, the autoclaved levocarnitine chloride solution was as stable as the non-autoclaved one. In conclusion, the method employed in our hospital for the preparation of levocarnitine chloride for infants is appropriate and is recommended as a standard medicine supply method among different facilities.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 126 (9), 805-809, 2006-09-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001206126685056
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- NII Article ID
- 110006154991
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 8084209
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- PubMed
- 16946594
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed