Consideration of Preventing Local Venous Pain by Dacarbazine
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- Ohtsubo Tatsuya
- Department of Pharmacy, Japanese Red Cross Kyoto Daini Hospital
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- Tsuji Takumi
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Umeyama Takayo
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Sudou Miho
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Komesu Kana
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Matsumoto Minako
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Yoshida Yuya
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Banno Rie
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Tomogane Kanji
- Department of Pharmacy, Japanese Red Cross Kyoto Daini Hospital
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- Fujita Atsuo
- Department of Pharmacy, Japanese Red Cross Kyoto Daini Hospital
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- Kohno Takeyuki
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Mikami Tadashi
- Department of Pharmacy, Japanese Red Cross Kyoto Daini Hospital
Bibliographic Information
- Other Title
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- ダカルバジン投与における血管痛対策の検討
- ダカルバジン トウヨ ニ オケル ケッカンツウ タイサク ノ ケントウ
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Abstract
Local venous pain caused by dacarbazine (DTIC) injection is due to its photodegradation product 5-diazoimidazole-4-carboxamide (Diazo-IC). The production of Diazo-IC can be decreased by protecting the drug from light. Furthermore, the production of Diazo-IC reportedly increases with time; however, there are no studies reporting the association between the injection preparation time and local venous pain caused by the DTIC injection. We evaluated the efficacy of the following: (1) method used to shorten the injection preparation time and (2) method used to change the diluting solution for DTIC. We found that shortening the injection preparation time tended to decrease the local venous pain expression due to DTIC, and Veen F decreased the production of Diazo-IC compared with the normal saline and 5% glucose solution. These results indicate that shortening the injection preparation time may be effective in preventing the local venous pain caused by the DTIC injection; moreover, using Veen F for DTIC may also reduce the pain.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 137 (3), 363-369, 2017-03-01
The Pharmaceutical Society of Japan