{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206128635520.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/yakushi.131.463"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"11032320"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/11032320"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I11032320"}},{"identifier":{"@type":"URI","@value":"https://dl.ndl.go.jp/pid/10204078"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/yakushi/131/3/131_3_463/_pdf"}},{"identifier":{"@type":"PMID","@value":"21372544"}},{"identifier":{"@type":"NAID","@value":"130000678912"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2011303675"}}],"dc:title":[{"@language":"en","@value":"Dose Conversion in Opioid Rotation from Continuous Intravenous Infusion of Morphine Hydrochloride Injection to Fentanyl Patch in the Management of Cancer Pain"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Opioid rotation has been proposed for management of cancer pain. No studies directly investigating dose equivalence between morphine injection (continuous IV administration) and the transdermal fentanyl patch have been reported. Therefore, we examined dose conversion ratios in patients undergoing opioid rotation from morphine injection to fentanyl patches. The subjects consisted of 45 patients admitted to Kitasato University East Hospital. Medical records were consulted to determine the “basic dose of morphine injection immediately prior to rotation” and the “basic dose of fentanyl patch after rotation”. Equivalent doses and conversion ratios obtained with the expression of (daily dose of morphine injection (mg)/daily delivered dose of fentanyl patch (mg)) were determined from the relationship between the data by regression analysis. The regression equation obtained was Y=50.882X-13.96, <i>r</i><sup>2</sup>=0.8922, where X and Y are daily doses of morphine injection and fentanyl patch, respectively. Equivalent doses and conversion ratios for daily dose of morphine injection (mg): daily delivered dose of fentanyl patch (mg) (patch dose mg/3 days) were 16.6 mg: 0.6 mg (2.5 mg)=28:1, 47.1 mg: 1.2 mg (5 mg) = 39:1 and 169.2 mg: 3.6 mg (15 mg)=47:1. In other reports, the ratio of morphine <i>vs</i>. fentanyl at 50:1 had no relation to the dose. While the present study suggested that in opioid rotation from low dose, 50:1 is not enough for the fentanyl patch. The dose conversion ratio of morphine injection to fentanyl patch was different at the low doses and high doses of morphine.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001206128635648","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283474469"},{"@type":"NRID","@value":"9000020627847"},{"@type":"NRID","@value":"9000021355512"},{"@type":"NRID","@value":"9000403990326"},{"@type":"NRID","@value":"9000405885243"},{"@type":"KAKEN_RESEARCHERS","@value":"50458759"},{"@type":"NRID","@value":"1000050458759"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kitasato"}],"foaf:name":[{"@language":"ja","@value":"川野 千尋"},{"@language":"en","@value":"KAWANO Chihiro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"北里大学薬学部　薬物治療学II (北里大学東病院）"},{"@language":"en","@value":"Pharmacy Practice and Science II (Kitasato University East Hospital), School of Pharmacy, Kitasato University"},{"@language":"en","@value":"Department of Pharmacy, Kitasato University East Hospital"},{"@language":"ja","@value":"北里大学東病院薬剤部"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204774991360","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020627850"},{"@type":"NRID","@value":"9000388536028"},{"@type":"NRID","@value":"9000255932998"},{"@type":"NRID","@value":"9000240193466"},{"@type":"NRID","@value":"9000015161709"},{"@type":"NRID","@value":"9000255932995"},{"@type":"NRID","@value":"9000367017032"},{"@type":"NRID","@value":"9000409499795"},{"@type":"NRID","@value":"9000259342670"},{"@type":"NRID","@value":"9000282424108"},{"@type":"NRID","@value":"9000256472432"},{"@type":"NRID","@value":"9000241758835"},{"@type":"NRID","@value":"9000005282093"},{"@type":"NRID","@value":"9000403990331"},{"@type":"NRID","@value":"9000256475044"},{"@type":"NRID","@value":"9000405885245"},{"@type":"KAKEN_RESEARCHERS","@value":"90383661"},{"@type":"NRID","@value":"1000090383661"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hirayamatakeshi"}],"foaf:name":[{"@language":"en","@value":"HIRAYAMA Takeshi"},{"@language":"ja","@value":"平山 武司"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmacy Practice and Science II (Kitasato University East Hospital), School of Pharmacy, Kitasato University"},{"@language":"ja","@value":"北里大学薬学部　薬物治療学II (北里大学東病院）"},{"@language":"en","@value":"Department of Pharmacy, Kitasato University East Hospital"},{"@language":"ja","@value":"北里大学東病院薬剤部"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206128635520","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020627853"}],"foaf:name":[{"@language":"ja","@value":"黒山 政一"},{"@language":"en","@value":"KUROYAMA Masakazu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmacy Practice and Science II (Kitasato University East Hospital), School of Pharmacy, Kitasato University"},{"@language":"ja","@value":"北里大学薬学部　薬物治療学II (北里大学東病院）"},{"@language":"en","@value":"Department of Pharmacy, Kitasato University East Hospital"},{"@language":"ja","@value":"北里大学東病院薬剤部"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00316903"},{"@type":"EISSN","@value":"13475231"},{"@type":"CODEN","@value":"YKKZAJ"},{"@type":"NDL_BIB_ID","@value":"000000023278"},{"@type":"ISSN","@value":"00316903"},{"@type":"LISSN","@value":"00316903"},{"@type":"NCID","@value":"AN00284903"}],"prism:publicationName":[{"@language":"en","@value":"YAKUGAKU ZASSHI"},{"@language":"en","@value":"YAKUGAKU ZASSHI"},{"@language":"ja","@value":"薬学雑誌"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2011-03-01","prism:volume":"131","prism:number":"3","prism:startingPage":"463","prism:endingPage":"467"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/11032320"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I11032320"},{"@id":"https://dl.ndl.go.jp/pid/10204078"},{"@id":"https://www.jstage.jst.go.jp/article/yakushi/131/3/131_3_463/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2011303675"}],"availableAt":"2011-03-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=dose%20conversion","dc:title":"dose conversion"},{"@id":"https://cir.nii.ac.jp/all?q=opioid%20rotation","dc:title":"opioid rotation"},{"@id":"https://cir.nii.ac.jp/all?q=morphine%20hydrochloride","dc:title":"morphine hydrochloride"},{"@id":"https://cir.nii.ac.jp/all?q=fentanyl%20patch","dc:title":"fentanyl patch"},{"@id":"https://cir.nii.ac.jp/all?q=cancer%20pain","dc:title":"cancer pain"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145685317376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Controlled-release oxycodone and morphine in cancer related pain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569905955840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Morphine kinetics during and after renal transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045729024896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Pharmacokinetics of Morphine"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996266964864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Opioid rotation for cancer pain"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893559702656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Accuracy in Equianalgesic 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