書誌事項
- タイトル別名
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- Elucidation of Accelerated Blood Clearance Phenomenon Caused by Repeat Injection of PEGylated Nanocarriers
- PEGカ ナノキャリアヒンカイ トウヨ ニ ヨル accelerated blood clearance ゲンショウ ノ キコウ カイメイ
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抄録
Liposomes modified with polyethylene glycol (PEG) can stably exist in the bloodstream because the PEG on the liposomes attracts a water shell to the liposomal surface. Since these liposomes are long circulating nanocarriers, they are used as drug and gene delivery tools. Repeat injection of PEGylated liposomes, however, is known to induce the accelerated blood clearance (ABC) phenomenon. In the ABC phenomenon, PEGylated liposomes that are injected subsequent to the first injection are cleared rapidly from the bloodstream and accumulate in the liver, resulting in loss of their long-circulating characteristics. The induction of ABC phenomenon is related to the production of anti-PEG IgM from splenic B cells. To elucidate the mechanism of the phenomenon, we firstly examined the relationship between the induction of ABC phenomenon and the concentration of PEGylated liposomes, and observed that the high dose of those did not induce the phenomenon. Next, we investigated whether polymeric micelles trigger ABC phenomenon or not. Finally, the size-dependency of ABC phenomenon was investigated by use of variously sized PEGylated liposomes and polymeric micelles having PEG chains. Our data suggest that the initiation of ABC phenomenon would be size-dependent, and particles smaller than 30 nm did not induce ABC phenomenon. We anticipate that the elucidation of the ABC phenomenon will be helpful for the development of DDS formulations.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 129 (12), 1445-1451, 2009-12-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001206128807680
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- NII論文ID
- 130000136135
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- NII書誌ID
- AN00284903
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- COI
- 1:CAS:528:DC%2BC3cXitlahsLc%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 10454957
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- PubMed
- 19952519
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可