Bis(alkylaminoalkoxy-2-benzofuranyl)ketone 誘導体及び Bis(acyloxy-2-benzofuranyl)ketone 誘導体の合成と抗 Virus 活性について

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タイトル別名
  • Synthesis and Antiviral Activity of Bis(alkylaminoalkoxy-2-benzofuranyl)ketone Derivatives and Bis(acyloxy-2-benzofuranyl)ketone Derivatives
  • Bis alkyl aminoalkoxy 2 benzofura

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説明

Bis(alkylaminoalkoxy-2-benzofuranyl)ketone (IIa-o) were synthesized by the reaction of alkylaminoalkyl halide with bis(hydroxy-2-benzofuranyl)ketones (I). Bis(alkylaminoalkoxy-2-benzofuranyl)keton N, N-dioxides (IIIa, b) were prepared from II by treatment with hydrogen peroxide. Bis(acyloxy-2-benzofuranyl)ketones (IVa-q) were synthesized by the reaction of acid chloride and acid anhydride with I. Bis(6-acetoxy-2-benzofuranyl)ketone (IVb) showed the most potent inhibitory activity on the multiplication of influenza virus in vitro. Bis(7-diethylaminoethoxy-2-benzofuranyl)ketone N, N-dioxide (IIIa) showed a potent interferon inducing activity in mice. IVb and IIIa given orally were effective against the infection of an influenza virus in mice.

収録刊行物

  • 薬学雑誌

    薬学雑誌 106 (1), 27-35, 1986

    公益社団法人 日本薬学会

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