{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206278721536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11250/chemotherapy1953.18.334"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"8098047"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/8098047"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I8098047"}},{"identifier":{"@type":"NAID","@value":"130004190977"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1971000979"}}],"dc:title":[{"@language":"en","@value":"<I>IN VITRO</I> ANTIMICROBIAL ACTIVITY OF RIFAMPICIN"},{"@value":"Rifampicinの<I>in vitro</I>抗菌作用"},{"@language":"ja-Kana","@value":"Rifampicin ノ in vitro コウキン サヨウ"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"Comparative <I>in vitro</I> evaluation was made between rifampicin and rifamycin SV. Minimum inhibitory concentrations were estimated by two-fold agar-plate dilution method. Each test strain was cultured overnight in Trypto-soy broth, one loopful of which was streaked on test agar-plate, and MICs were determined after 24 hours incubation at 37°C.<BR>Rifampicin showed very high activity against GRAM-positive bacteria, and was also moderately effective against many species of GRAM-negative rods, whereas rifamycin SV was confirmed to be less active against GRAM-positive bacteria and quite inactive against GRAM-negative species.<BR>One hundred clinical isolates of <I>Staph. aureus</I>, including multiple-resistant strains, were completely suppressed below 0.006mcg/ml of rifampicin, the activity being higher by far than other antibiotics. However, against strains of <I>Shigella</I> and <I>E. coli</I>, MICs of rifampicin ranged 6.25-42.5 mcg/ml, less active as compared with those of chloramphenicol or tetracycline. Among <I>Proteus, Klebsiella</I> and <I>Pseudomonas</I>, strains of <I>Proteae</I> were most susceptible to rifampicin, the MICs being ranged below 25 mcg/ ml.<BR>Changes in various experimental conditions of <I>in vitro</I> testing such as kinds and reactions of the test media, and the sizes of inocula did not cause any noticeable fluctuation of MIC.<BR>These observations as well as the experimental data on the absorption and tissue distributions of rifampicin strongly suggest that this substance may be highly effective against infections due to GRAM-positive bacteria, and also useful for the infections due to GRAM-negative rods."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410009222119888897","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256142859"}],"foaf:name":[{"@language":"en","@value":"GOTO SACHIKO"},{"@language":"ja","@value":"五島 瑳智子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Microbiology, Toho University School of Medicine, Tokyo"},{"@language":"ja","@value":"東邦大学医学部微生物学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009222119888898","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256142860"}],"foaf:name":[{"@language":"en","@value":"KANEKO YASUKO"},{"@language":"ja","@value":"金子 康子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Microbiology, Toho University School of Medicine, Tokyo"},{"@language":"ja","@value":"東邦大学医学部微生物学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009222119888896","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256142861"}],"foaf:name":[{"@language":"en","@value":"KUWAHARA SHOGO"},{"@language":"ja","@value":"桑原 章吾"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Microbiology, Toho University School of Medicine, Tokyo"},{"@language":"ja","@value":"東邦大学医学部微生物学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00093165"},{"@type":"EISSN","@value":"18845894"},{"@type":"NDL_BIB_ID","@value":"000000000101"},{"@type":"ISSN","@value":"00093165"},{"@type":"LISSN","@value":"00093165"},{"@type":"NCID","@value":"AN00186653"}],"prism:publicationName":[{"@language":"en","@value":"CHEMOTHERAPY"},{"@language":"ja","@value":"ＣＨＥＭＯＴＨＥＲＡＰＹ"},{"@language":"en","@value":"Chemother."},{"@language":"ja","@value":"ＣＨＥＭＯＴＨＥＲＡＰＹ"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Chemotherapy"},{"@language":"ja","@value":"公益社団法人 日本化学療法学会"}],"prism:publicationDate":"1970","prism:volume":"18","prism:number":"3","prism:startingPage":"334","prism:endingPage":"338"},"url":[{"@id":"http://id.ndl.go.jp/bib/8098047"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I8098047"},{"@id":"https://search.jamas.or.jp/link/ui/1971000979"}],"availableAt":"1970","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0037895635"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I8098047"},{"@type":"CIA","@value":"130004190977"}]}