書誌事項
- タイトル別名
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- THE MODE OF ANTIBACTERIAL ACTION OF NITROFURAN COMPOUNDS
- Nitrofuran ケイ ヤクザイ ノ コウキン サヨウ ヨウシキ
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説明
The antibacterial activity of two nitrofurans, 3-dihydroxymethylamino-6- [2- (5-nitro-2-furyl) vinyl] -1, 2, 4-triazine (Panfuran-S : FT) and 2-[2-(5-nitro-2-furyl) vinyl] -quinoline (NFQ) was examined. The experimental results determining growth rates, viable counts (Fig. 1, 2, 4, and 5), and biomacromolecules (Fig. 3 and 6) in the presence of the nitrofurans suggested that the potent growth inhibitory action of these drugs againstEscherichia coliQ13 orStaphylococcus aureusE642-1 could apparently be associated with the interference of DNA synthesis. Mutants ofE. coli, such as the DNA polymerase I-deficient mutantPolAl and the recombination-deficient mutant rec A13, exhibited much higher sensitivity to the nitrofurans than the corresponding parent strains did (Fig. 7, Table 2 and 3). The results indicate the close relationship between the mechanism of inhibition by the nitrofurans and the ability to repair the DNA damage caused by these drugs in the bacterial strains.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 22 (7), 1159-1164, 1974
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206279646464
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- NII論文ID
- 130004191545
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- NII書誌ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL書誌ID
- 7494199
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可