{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206287327872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11250/chemotherapy1953.36.supplement3_895"}},{"identifier":{"@type":"NAID","@value":"130004196264"}}],"dc:title":[{"@language":"en","@value":"CLINICAL STUDY ON TE-031 (A-56268) IN OTORHINOLARYNGOLOGY"},{"@value":"TE-031の耳鼻咽喉科領域における臨床的研究"}],"description":[{"type":"abstract","notation":[{"@language":"en","@value":"We studied TE-031 (A-56268) for its clinical and bacteriological usefulness in otorhinolaryngology.<BR>1. 100 mg or 200 mg of TE-031 was administered orally twice daily, before or after meals.<BR>2. TE-031 was administered to 7 patients with acute tonsillitis, 2 with otitis media and 3 with paranasal sinusitis.<BR>3. Clinical efficacy in these infections was tonsillitis 100%, otitis media 100%, and paranasal sinusitis 67%. The overall efficacy rate was 91.7%.<BR>4. Bacteriologically, one strain was isolated in each case, and the bacteriological eradication rate was 91.7%.<BR>5. No adverse events or abnormal laboratory findings were observed in any patient.<BR>From the above results, we consider TE-031 to be a safe and useful drug in otorhinolaryngological infections at a dose of 100 or 200 mg twice daily."},{"@value":"新経口マクロライド系薬剤であるTE-031の耳鼻咽喉科領域感染症における有用性を検討した。<BR>1. TE-0311回100 mgないし1回200 mgを1日2回, 食前または食後に経口投与した。<BR>2. 急性扁桃炎7例, 中耳炎2例, 副鼻腔炎3例の合計12例にTE-031を投与した。<BR>3. 臨床効果は, 扁桃炎100%, 中耳炎100%, 副鼻腔炎67%であり, 全体では91.7%であった。<BR>4. 細菌学的には, いずれも単独菌検出例であり, 91.7%の除菌率であった。<BR>5. 副作用および臨床検査値異常は認めなかった。<BR>以上より, 本剤は1回100 mgないし2001mg, 1日2回投与にて, 耳鼻咽喉科領域感染症には有用性が期待される安全な薬剤であると考える。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410290697167032960","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256170431"}],"foaf:name":[{"@language":"en","@value":"KAWAMURA SHOZO"},{"@language":"ja","@value":"河村 正三"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology, School of Medicine, Juntendo University"},{"@language":"ja","@value":"順天堂大学医学部耳鼻咽喉科学教室"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697167032961","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256170432"}],"foaf:name":[{"@language":"en","@value":"WATANABE HIROSHI"},{"@language":"ja","@value":"渡辺 洋"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology, Taketani Hospital"},{"@language":"ja","@value":"武谷病院耳鼻咽喉科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697167032962","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000256170430"}],"foaf:name":[{"@language":"en","@value":"FUJIMAKI YUTAKA"},{"@language":"ja","@value":"藤巻 豊"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Otorhinolaryngology, School of Medicine, Juntendo University"},{"@language":"ja","@value":"順天堂大学医学部耳鼻咽喉科学教室"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00093165"},{"@type":"EISSN","@value":"18845894"}],"prism:publicationName":[{"@language":"en","@value":"CHEMOTHERAPY"},{"@language":"ja","@value":"ＣＨＥＭＯＴＨＥＲＡＰＹ"},{"@language":"en","@value":"Chemother."},{"@language":"ja","@value":"ＣＨＥＭＯＴＨＥＲＡＰＹ"}],"dc:publisher":[{"@language":"en","@value":"Japanese Society of Chemotherapy"},{"@language":"ja","@value":"公益社団法人 日本化学療法学会"}],"prism:publicationDate":"1988","prism:volume":"36","prism:number":"Supplement3","prism:startingPage":"895","prism:endingPage":"899"},"availableAt":"1988","dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0037902444"},{"@type":"CIA","@value":"130004196264"}]}