{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206292631680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4327/jsnfs.67.171"}},{"identifier":{"@type":"URI","@value":"https://oka-pu.repo.nii.ac.jp/records/1246"}},{"identifier":{"@type":"URI","@value":"https://agriknowledge.affrc.go.jp/RN/2010873076"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"025774759"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/025774759"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I025774759"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jsnfs/67/4/67_171/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004679327"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2014340015"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Physiological Function of Acetate"},{"@language":"ja","@value":"酢酸の生理機能性"},{"@language":"ja-Kana","@value":"サクサン ノ セイリ キノウセイ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Acetate is an endogenous metabolite of fatty acid <i>β</i>-oxidation produced in the liver mitochondria under conditions of starvation. Orally administered acetate is immediately taken up from the intestine and excreted into the bloodstream. The acetate is then absorbed by tissues and activates AMP-activated protein kinase (AMPK) by increasing the AMP/ATP ratio. AMPK acts as the key metabolic master switch, and regulates a number of enzymes involved in lipid homeostasis. Treatment with acetate results in a marked reduction of lipid accumulation in adipose tissue, protection against accumulation of fat in the liver, and improves glucose tolerance. It decreases the transcripts of lipogenic genes in the liver, indicating inhibition of lipogenesis in that organ. Furthermore, acetate treatment results in a higher rate of oxygen consumption and a smaller size of lipid droplets in white and brown adipose tissues. These results indicate that acetate is formed endogenously under conditions of starvation and utilized as a biological fuel, wheras acetate taken up under fed conditions has potential to prevent obesity and obesity-linked type 2 diabetes."},{"@language":"ja","@value":"酢酸は, 生体において空腹時に脂肪酸から<i>β</i>酸化により生成される内因性の成分であり, 骨格筋などで生体燃料として利用される。一方, 外因性に酢酸を摂取すると酢酸は容易に血中に移行し組織に速やかに取り込まれた後, その代謝過程でAMPを生成し細胞内のAMP/ATP比を増加させてAMPキナーゼ (AMPK) を活性化させる。2型糖尿病の病態モデル動物に酢酸を継続的に摂取させると, 肥満が抑制され耐糖能を改善させる。また肝臓において脂肪合成関連遺伝子の転写量を低下させることから, 酢酸は脂肪合成を抑制するように作用すると示唆される。その他エネルギー消費割合の増加, 白色および褐色脂肪組織においては脂肪滴肥大化の抑制が見られる。以上より酢酸は空腹時には内因性の成分として生成され生体燃料として利用されるが, 摂食時に酢酸を摂取すると脂肪合成の抑制による肥満の抑制, さらに肥満に起因した2型糖尿病予防効果をもたらすと示唆される。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276165931264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70254563"},{"@type":"NRID","@value":"1000070254563"},{"@type":"NRID","@value":"9000004248002"},{"@type":"NRID","@value":"9000414495927"},{"@type":"NRID","@value":"9000241840519"},{"@type":"NRID","@value":"9000411769353"},{"@type":"NRID","@value":"9000020133756"},{"@type":"NRID","@value":"9000259839492"},{"@type":"NRID","@value":"9000347403384"}],"foaf:name":[{"@language":"en","@value":"Yamashita Hiromi"},{"@language":"ja","@value":"山下 広美"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"岡山県立大学保健福祉学部栄養学科"},{"@language":"en","@value":"Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02873516"},{"@type":"LISSN","@value":"02873516"},{"@type":"EISSN","@value":"18832849"},{"@type":"CODEN","@value":"NESGDC"},{"@type":"ISSN","@value":"02873516"},{"@type":"NDL_BIB_ID","@value":"000000037891"},{"@type":"NCID","@value":"AN00311992"}],"prism:publicationName":[{"@language":"en","@value":"Nippon Eiyo Shokuryo Gakkaishi"},{"@language":"ja","@value":"日本栄養・食糧学会誌"},{"@language":"en","@value":"J Jpn Soc Nutr Food Sci"},{"@language":"en","@value":"Journal of Japanese Society of Nutrition and Food Science"},{"@language":"en","@value":"Nippon Eiyo Shokuryo Gakkaishi"},{"@language":"ja","@value":"日本栄養・食糧学会誌"},{"@language":"en","@value":"JJSNFS"},{"@language":"en","@value":"Nippon Eiyo Shokuryo Gakkaishi"},{"@language":"ja","@value":"栄食誌"}],"dc:publisher":[{"@language":"en","@value":"Japan Society of Nutrition and Food Science"},{"@language":"ja","@value":"公益社団法人 日本栄養・食糧学会"}],"prism:publicationDate":"2014","prism:volume":"67","prism:number":"4","prism:startingPage":"171","prism:endingPage":"176"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://oka-pu.repo.nii.ac.jp/records/1246"},{"@id":"https://agriknowledge.affrc.go.jp/RN/2010873076"},{"@id":"http://id.ndl.go.jp/bib/025774759"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I025774759"},{"@id":"https://www.jstage.jst.go.jp/article/jsnfs/67/4/67_171/_pdf"},{"@id":"http://id.nii.ac.jp/1212/00001232/"},{"@id":"https://search.jamas.or.jp/link/ui/2014340015"}],"availableAt":"2014","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=acetate","dc:title":"acetate"},{"@id":"https://cir.nii.ac.jp/all?q=vinegar","dc:title":"vinegar"},{"@id":"https://cir.nii.ac.jp/all?q=biological%20fuel","dc:title":"biological fuel"},{"@id":"https://cir.nii.ac.jp/all?q=obesity","dc:title":"obesity"},{"@id":"https://cir.nii.ac.jp/all?q=lipid%20metabolism","dc:title":"lipid metabolism"},{"@id":"https://cir.nii.ac.jp/all?q=%E9%85%A2%E9%85%B8","dc:title":"酢酸"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%94%9F%E4%BD%93%E7%87%83%E6%96%99","dc:title":"生体燃料"},{"@id":"https://cir.nii.ac.jp/all?q=AMP%E3%82%AD%E3%83%8A%E3%83%BC%E3%82%BC","dc:title":"AMPキナーゼ"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%82%A5%E6%BA%80","dc:title":"肥満"},{"@id":"https://cir.nii.ac.jp/all?q=%E8%84%82%E8%B3%AA%E4%BB%A3%E8%AC%9D","dc:title":"脂質代謝"}],"dcterms:subject":[{"subjectScheme":"Other","notation":[{"@value":"酢酸"}]},{"subjectScheme":"Other","notation":[{"@value":"生体燃料"}]},{"subjectScheme":"Other","notation":[{"@value":"AMPキナーゼ"}]},{"subjectScheme":"Other","notation":[{"@value":"肥満"}]},{"subjectScheme":"Other","notation":[{"@value":"脂質代謝"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"acetate"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"vinegar"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"biological fuel"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"obesity"}]},{"subjectScheme":"Other","notation":[{"@language":"en","@value":"lipid metabolism"}]}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257187787136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24580195"},{"@type":"JGN","@value":"JP24580195"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24580195/"}],"notation":[{"@language":"ja","@value":"酢酸の骨格筋におよぼす作用を介した抗肥満・抗老化の効果に関する研究"},{"@language":"en","@value":"Effects of acetic acid on anti-obesity and anti-aging via its function for skeletal muscle"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145179360000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ETHANOL METABOLISM AND PRODUCTION OF FREE ACETATE IN THE HUMAN LIVER"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145917929856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acetyl-CoA Synthetase 2, a Mitochondrial Matrix Enzyme Involved in the Oxidation of Acetate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095839702656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Distribution and utilization of alcohol-derived acetate in the rat."}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568434480000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production and utilization of acetate in mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570724882688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044418135040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production and Utilization of Free Acetate in Man"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519497618048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995169090304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469944905344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanism for Fatty Acid “Sparing” Effect on Glucose-induced Transcription"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419413229440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895003788288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843460976000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP‐activated protein kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845566242304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845673918080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318715566336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of acetate in the liver and its utilization in peripheral tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319750990720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795528157568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268711086208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphorylation control of cardiac acetyl‐CoA carboxylase by cAMP‐dependent protein kinase and 5′‐AMP activated protein kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268936863616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Supply and utilization of acetate in mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206479335296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Improvement of Obesity and Glucose Tolerance by Acetate in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats"},{"@value":"Involvement of obesity and glucose tolerance by acetate in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681301081600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Purification and Partial Characterization of Acetyl-CoA Synthetase in Rat Liver Mitochondria."}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681453946112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of a Hypolipidemic Drug, Di (2-ethylhexyl) phthalate, on mRNA-Expression Associated Fatty Acid and Acetate Metabolism in Rat Tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681455778304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Vinegar Intake Reduces Body Weight, Body Fat Mass, and Serum Triglyceride Levels in Obese Japanese Subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681456670336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Acetate on Lipid Metabolism in Muscles and Adipose Tissues of Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1003852395"},{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:01082:0000727277"},{"@type":"IRDB","@value":"oai:irdb.nii.ac.jp:03420:0004274952"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I025774759"},{"@type":"CROSSREF","@value":"10.4327/jsnfs.67.171"},{"@type":"CIA","@value":"130004679327"},{"@type":"KAKEN","@value":"PRODUCT-14677574"},{"@type":"OPENAIRE","@value":"doi_dedup___::eedfd869d80248efacfda24ce0cc8416"}]}