書誌事項
- タイトル別名
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- Prophylactic Effects of Sesamin on Ischemic Cerebral Injury in Stroke-Prone Spontaneously Hypertensive Rats.
- ノウソッチュウ イハッショウセイ コウケツアツ シゼン ハッショウ ラット ノ
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抄録
As part of a basic study on the prevention of ischemic cerebral injury, sesamin (5g/kg Funabashi SP diet) was administered to stroke-prone spontaneously hypertensive rats (SHRSP) for 8 weeks from 8 weeks of age, and pathological and biochemical changes in the cerebral cortex were examined and compared with those in normotensive Wistar-Kyoto rats (WKY). In the control SHRSP, cerebral softening was found in 4 of 8 rats (50%), whereas no pathological changes were evident in sesamin-treated rats. In control SHRSP, the uric acid content of the cerebral cortex was extremely high in comparison with that in control WKY, but it was significantly lower (p<0.05) in sesamin-treated SHRSP. On the other hand, superoxide dismutase (SOD) activity was lower (p<0.05) and Na/K-ATPase was higher (p<0.05) in sesamin-treated SHRSP than in WKY. These results indicate that lipid peroxidation caused by free radicals is an important factor in ischemic cerebral injury, and that sesamin plays an important role in the scavenging of free radicals, thus preventing cerebral softening in SHRSP.
収録刊行物
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- 日本栄養・食糧学会誌
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日本栄養・食糧学会誌 48 (3), 189-193, 1995
公益社団法人 日本栄養・食糧学会
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詳細情報 詳細情報について
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- CRID
- 1390001206293124864
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- NII論文ID
- 10008562481
- 10006061464
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- NII書誌ID
- AN00311992
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- COI
- 1:CAS:528:DyaK2MXmvFyksbs%3D
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- ISSN
- 18832849
- 02873516
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- NDL書誌ID
- 3619513
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可