{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206325215744.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3177/jnsv.59.454"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DC%2BC3sXhslGht7rM"}},{"identifier":{"@type":"PMID","@value":"24418880"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"024965672"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/024965672"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I024965672"}},{"identifier":{"@type":"NAID","@value":"130003393739"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2014149997"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Mice That Are Fed a High-Fat Diet Display Increased Hepcidin Expression in Adipose Tissue"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Since the discovery that hepcidin is expressed in the adipose tissue of obese subjects, attention has been increasingly focused on alterations in iron homeostasis that are associated with adiposity. We examined the production of hepcidin, the expression of hepcidin-related genes and the iron content of the adipose tissue in obesity using Swiss mice fed a high-fat diet (HFD). The mice were maintained on a control diet or HFD for 12 or 24 wk, and body weight, adiposity and glucose homeostasis were evaluated. The expression of several genes (<i>hepcidin</i>, <i>TfR1</i>,<i> TfR2</i>,<i> DMT1</i>,<i> FT-heavy</i>,<i> ferroportin</i>,<i> IRP-1</i>,<i> IRP-2 and HIF-1</i>) and the protein expression of hepcidin and IL-6 were quantified. The iron level was assessed using a Prussian blue reaction in paraffin-embedded tissue. After 24 wk on the HFD, we observed increases in the levels of hepcidin in the serum and the visceral adipose tissue. The IL-6 levels also increased in the visceral adipose tissue. Adipocytes isolated from the visceral adipose tissues of lean and obese mice expressed <i>hepcidin</i> at comparable levels; however, isolated macrophages from the stromal vascular fraction expressed higher <i>hepcidin</i> levels. Adipose tissues from obese mice displayed increased<i> tfR2</i> expression and the presence of iron. Our results indicate that IL-6 and iron may affect the signaling pathways governing hepcidin expression. Thus, the mice fed HFD for 24 wk represent a suitable model for the study of obesity-linked hepcidin alterations. In addition, hepcidin may play local roles in controlling iron availability and interfering with inflammation in adipose tissue."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001206325215750","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000243889299"}],"foaf:name":[{"@language":"en","@value":"GOTARDO Érica Martins Ferreira"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206325215748","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000243889300"}],"foaf:name":[{"@language":"en","@value":"SANTOS Aline Noronha dos"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206325215744","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000243889301"}],"foaf:name":[{"@language":"en","@value":"MIYASHIRO Renan Akira"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206325215746","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000243889302"}],"foaf:name":[{"@language":"en","@value":"GAMBERO Sheley"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206325215749","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000243889303"}],"foaf:name":[{"@language":"en","@value":"ROCHA Thalita"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206325215745","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000243889304"}],"foaf:name":[{"@language":"en","@value":"RIBEIRO Marcelo Lima"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206325215747","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000243889305"}],"foaf:name":[{"@language":"en","@value":"GAMBERO Alessandra"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Clinical Pharmacology and Gastroenterology Unit, Sao Francisco University Medical School"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03014800"},{"@type":"LISSN","@value":"03014800"},{"@type":"EISSN","@value":"18817742"},{"@type":"CODEN","@value":"JNSVA5"},{"@type":"NDL_BIB_ID","@value":"000000119513"},{"@type":"ISSN","@value":"03014800"},{"@type":"NCID","@value":"AA00703822"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Nutritional Science and Vitaminology"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ"},{"@language":"en","@value":"J Nutr Sci Vitaminol"},{"@language":"en","@value":"JNSV"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ"},{"@language":"en","@value":"Journal of Nutritional Science and Vitaminology, J Nutr Sci Vitaminol"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ，　Ｊ　Ｎｕｔｒ　Ｓｃｉ　Ｖｉｔａｍｉｎｏｌ"},{"@language":"en","@value":"Journal of Nutritional Science and Vitaminology"}],"dc:publisher":[{"@language":"en","@value":"Center for Academic Publications Japan"},{"@language":"ja","@value":"一般財団法人 学会誌刊行センター"}],"prism:publicationDate":"2013","prism:volume":"59","prism:number":"5","prism:startingPage":"454","prism:endingPage":"461"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/024965672"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I024965672"},{"@id":"https://search.jamas.or.jp/link/ui/2014149997"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=high-fat%20diet%20model","dc:title":"high-fat diet model"},{"@id":"https://cir.nii.ac.jp/all?q=IL-6","dc:title":"IL-6"},{"@id":"https://cir.nii.ac.jp/all?q=iron","dc:title":"iron"},{"@id":"https://cir.nii.ac.jp/all?q=adipocyte","dc:title":"adipocyte"},{"@id":"https://cir.nii.ac.jp/all?q=macrophage","dc:title":"macrophage"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360292620419774208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interleukin-6 induces hepcidin expression through 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