Pathogenicity of Sendai Viruses Adapted into Polarized MDCK Cells.

DOI IR IR (HANDLE) Web Site Web Site View 1 Remaining Hide 56 References Open Access
  • Ratih AGUNGPRIYONO Dewi
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki 889-2155, Japan
  • YAMAGUCHI Ryoji
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki 889-2155, Japan
  • TOHYA Yukinobu
    Department of Veterinary Microbiology, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan
  • UCHIDA Kazuyuki
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki 889-2155, Japan
  • TATEYAMA Susumu
    Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Nishi 1-1, Gakuen Kibana Dai, Miyazaki 889-2155, Japan

Bibliographic Information

Other Title
  • 極性を有するMDCK細胞順化センダイウイルスの病原性

Search this article

Description

Apically and basally released Sendai viruses (SeV) were obtained after infection of polarized Madin-Darby canine kidney (MDCK) cells grown on permeable membrane culture inserts. After 20 passages of adaptation in MDCK cells, we compared their in vivo and in vitro pathogenicity with the parental Mol-strain of SeV. These viruses had comparable in vitro pathogenicity, but the in vivo pathogenicities were varied. The apically released MDCK-adapted virus showed comparable pathogenicity with the parental virus, in contrast with the basally released MDCK-adapted virus, which showed in vivo attenuation.

Journal

References(56)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top