Comparison of Molecular and Growth Properties for Two Different Canine Distemper Virus Clusters, Asia 1 and 2, in Japan

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  • LAN Nguyen Thi
    Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
  • YAMAGUCHI Ryoji
    Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
  • KAWABATA Atsushi
    Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
  • UCHIDA Kazuyuki
    Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki
  • SUGANO Sumio
    The Institute of Medical Science, The University of Tokyo
  • TATEYAMA Susumu
    Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki

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Other Title
  • 日本におけるアジア1型及び2型,異なるジステンパーウイルス2群の分子及び増殖性状の比較
  • 日本におけるアジア1型及び2型,異なるジステンバーウイルス2群の分子及び増殖性状の比較(ウイルス学)

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To compare the molecular and growth properties of two newly isolated canine distemper virus strains in the Asia 1 and 2 groups with clinico-pathological findings in dogs, nucleotide and predicted amino acid sequence comparisons of genes H and P were performed together with comparative growth profiling. The predicted amino acid sequences of the H gene contained 12 cysteine residues that were conserved among the examined Asia 1 and Asia 2 viruses. The hydrophobic region in the H gene of the Asia 2 isolates was one amino acid longer than that of the Asia 1 group. The H gene of the Asia 1 group had nine putative asparagine (N)-linked glycosylation sites, while there were eight sites in the Asia 2 group. The titers of the cell-associated viruses for the Asia 1 strains were higher than those of the released viruses and were opposite to those of the Asia 2 strains in a previous study. The molecular and growth properties of the Asia 1 and Asia 2 groups seem to vary, although no significant differences were observed in the clinical signs and pathological findings between the two groups.<br>

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