{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206436002048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.11277/stomatology.62.254"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"024942967"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/024942967"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I024942967"}},{"identifier":{"@type":"NAID","@value":"130004781800"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2014097305"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Prevention of the destruction of acinar structure in patients with Sjögren's syndrome"},{"@language":"ja","@value":"Sjögren症候群患者の唾液腺腺房構造破壊阻止"},{"@value":"Sjogren症候群患者の唾液腺腺房構造破壊阻止 : セファランチンの有効性に関する臨床病理学的研究"},{"@language":"ja-Kana","@value":"Sjogren ショウコウグン カンジャ ノ ダエキセンセン ボウ コウゾウ ハカイ ソシ : セファランチン ノ ユウコウセイ ニ カンスル リンショウ ビョウリガクテキ ケンキュウ"}],"dcterms:alternative":[{"@language":"en","@value":"—Clinicopathological study on the effectiveness of cepharanthin—"},{"@language":"ja","@value":"―セファランチンの有効性に関する臨床病理学的研究―"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Sjögren's syndrome (SS) is characterized by the eventual total replacement of the acinar structure by marked infiltration of lymphocytes into the salivary and lacrimal glands. We previously demonstrated that tumor necrosis factor-α (TNF-α) induced matrix metalloproteinase-9 (MMP-9) production by the stimulating transcription factor, nuclear factor-κB (NF-κB), in human salivary gland acinar cells and that cepharanthin, a biscoclaurine alkaloid, prevented the activation of TNF-α-induced NF-κB activity. In addition, we have shown that cepharanthin prevented the destruction of acinar tissues in murine SS. Thus, in this study, we investigated the clinicopathological effect of cepharanthin on the patients with SS. <br>Ten patients with a diagnosis of primary SS were enrolled in this study. They were treated with cepharanthin for three months, followed by the evaluation of salivary production, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-SS-A antibody, anti-SS-B antibody, pathological examination of labial salivary gland biopsy specimens, and the symptom of drymouth. <br>Average salivary production was 4.25ml/10minutes before the study. This average production increased to 6.46ml/10minutes after the study. There were no remarkable changes in CRP, ESR, anti-SS-A antibody and anti-SS-B antibody. In pathological findings, although the decreases in infiltration of lymphocytes were observed in 5 out of 5 cases, the reduction of destruction of acinar structures was clearly detected in 5 cases. Improvement of symptom of drymouth was detected in 7 out of 10 cases. <br>These observations suggest that cepharanthin treatment might provide an efficient and useful therapeutic approach for countering the destruction of acinar tissue in salivary glands of patients with SS."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326235037440","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70437391"},{"@type":"NRID","@value":"1000070437391"},{"@type":"NRID","@value":"9000391687973"},{"@type":"NRID","@value":"9000000978238"},{"@type":"NRID","@value":"9000399008136"},{"@type":"NRID","@value":"9000403971912"},{"@type":"NRID","@value":"9000396144911"},{"@type":"NRID","@value":"9000258055592"},{"@type":"NRID","@value":"9000258205025"},{"@type":"NRID","@value":"9000321628185"},{"@type":"NRID","@value":"9000283225545"},{"@type":"NRID","@value":"9000404119577"},{"@type":"NRID","@value":"9000283650615"},{"@type":"NRID","@value":"9000405123695"},{"@type":"NRID","@value":"9000399531239"},{"@type":"NRID","@value":"9000273005527"},{"@type":"NRID","@value":"9000413496377"},{"@type":"NRID","@value":"9000405660977"},{"@type":"NRID","@value":"9000255874512"},{"@type":"NRID","@value":"9000410145932"},{"@type":"NRID","@value":"9000018194178"},{"@type":"NRID","@value":"9000413496381"},{"@type":"NRID","@value":"9000413699882"},{"@type":"NRID","@value":"9000411500286"},{"@type":"NRID","@value":"9000402085768"},{"@type":"NRID","@value":"9000410145926"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/70437391"}],"foaf:name":[{"@language":"en","@value":"AOTA Keiko"},{"@language":"ja","@value":"青田 桂子"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"},{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751146450944","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00581406"},{"@type":"NRID","@value":"1000000581406"},{"@type":"NRID","@value":"9000397832771"},{"@type":"NRID","@value":"9000002006365"},{"@type":"NRID","@value":"9000283245540"},{"@type":"NRID","@value":"9000001200258"},{"@type":"NRID","@value":"9000412383292"},{"@type":"NRID","@value":"9000396144913"},{"@type":"NRID","@value":"9000409296862"},{"@type":"NRID","@value":"9000258205026"},{"@type":"NRID","@value":"9000283225546"},{"@type":"NRID","@value":"9000283711478"},{"@type":"NRID","@value":"9000273005531"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yamamura.yoshiko"}],"foaf:name":[{"@language":"en","@value":"YAMAMURA Yoshiko"},{"@language":"ja","@value":"山村 佳子"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"},{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853647057842820","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283225547"}],"foaf:name":[{"@language":"en","@value":"KANI Koichi"},{"@language":"ja","@value":"可児 耕一"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"},{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326208309888","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30380091"},{"@type":"NRID","@value":"1000030380091"},{"@type":"NRID","@value":"9000329442381"},{"@type":"NRID","@value":"9000391687970"},{"@type":"NRID","@value":"9000006629900"},{"@type":"NRID","@value":"9000283245538"},{"@type":"NRID","@value":"9000399008133"},{"@type":"NRID","@value":"9000001585694"},{"@type":"NRID","@value":"9000391688005"},{"@type":"NRID","@value":"9000258205021"},{"@type":"NRID","@value":"9000321628182"},{"@type":"NRID","@value":"9000283225548"},{"@type":"NRID","@value":"9000283711476"},{"@type":"NRID","@value":"9000283650616"},{"@type":"NRID","@value":"9000273005528"},{"@type":"NRID","@value":"9000405660974"},{"@type":"NRID","@value":"9000405632280"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/30380091"}],"foaf:name":[{"@language":"en","@value":"TAKANO Hideyuki"},{"@language":"ja","@value":"高野 栄之"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"},{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658792046212","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20335805"},{"@type":"NRID","@value":"1000020335805"},{"@type":"NRID","@value":"9000255874765"},{"@type":"NRID","@value":"9000283245536"},{"@type":"NRID","@value":"9000258077546"},{"@type":"NRID","@value":"9000258205024"},{"@type":"NRID","@value":"9000283225549"},{"@type":"NRID","@value":"9000283650614"},{"@type":"NRID","@value":"9000255874782"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0088264"}],"foaf:name":[{"@language":"ja","@value":"茂木 勝美"},{"@language":"en","@value":"MOTEGI Katsumi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"},{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751135005568","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00304543"},{"@type":"NRID","@value":"1000000304543"},{"@type":"NRID","@value":"9000329899467"},{"@type":"NRID","@value":"9000391687968"},{"@type":"NRID","@value":"9000000851508"},{"@type":"NRID","@value":"9000331456973"},{"@type":"NRID","@value":"9000283245537"},{"@type":"NRID","@value":"9000399008132"},{"@type":"NRID","@value":"9000398444680"},{"@type":"NRID","@value":"9000273025950"},{"@type":"NRID","@value":"9000391688004"},{"@type":"NRID","@value":"9000396144912"},{"@type":"NRID","@value":"9000258205020"},{"@type":"NRID","@value":"9000392846818"},{"@type":"NRID","@value":"9000321628180"},{"@type":"NRID","@value":"9000283225550"},{"@type":"NRID","@value":"9000283711477"},{"@type":"NRID","@value":"9000283650613"},{"@type":"NRID","@value":"9000399762093"},{"@type":"NRID","@value":"9000273011447"},{"@type":"NRID","@value":"9000405632282"},{"@type":"NRID","@value":"9000403957949"},{"@type":"NRID","@value":"9000410145935"},{"@type":"NRID","@value":"9000398444687"},{"@type":"NRID","@value":"9000413496385"},{"@type":"NRID","@value":"9000256675970"},{"@type":"NRID","@value":"9000410145930"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/00304543"}],"foaf:name":[{"@language":"ja","@value":"桃田 幸弘"},{"@language":"en","@value":"MOMOTA Yukihiro"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"},{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853647057842816","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283225551"}],"foaf:name":[{"@language":"en","@value":"ISHIMARU Naozumi"},{"@language":"ja","@value":"石丸 直澄"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"},{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"},{"@language":"en","@value":"Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"},{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔分子病態学分野"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658462720640","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20144983"},{"@type":"NRID","@value":"1000020144983"},{"@type":"NRID","@value":"9000394957451"},{"@type":"NRID","@value":"9000331456925"},{"@type":"NRID","@value":"9000398444681"},{"@type":"NRID","@value":"9000273025953"},{"@type":"NRID","@value":"9000258077545"},{"@type":"NRID","@value":"9000403971913"},{"@type":"NRID","@value":"9000396144918"},{"@type":"NRID","@value":"9000258205028"},{"@type":"NRID","@value":"9000321628181"},{"@type":"NRID","@value":"9000283225552"},{"@type":"NRID","@value":"9000404119578"},{"@type":"NRID","@value":"9000283711480"},{"@type":"NRID","@value":"9000283650618"},{"@type":"NRID","@value":"9000405123700"},{"@type":"NRID","@value":"9000399531242"},{"@type":"NRID","@value":"9000410264707"},{"@type":"NRID","@value":"9000273005532"},{"@type":"NRID","@value":"9000399762094"},{"@type":"NRID","@value":"9000403957950"},{"@type":"NRID","@value":"9000410145938"},{"@type":"NRID","@value":"9000398444689"},{"@type":"NRID","@value":"9000413496386"},{"@type":"NRID","@value":"9000413699885"},{"@type":"NRID","@value":"9000411500287"},{"@type":"NRID","@value":"9000402085773"},{"@type":"NRID","@value":"9000410145931"},{"@type":"NRID","@value":"9000255874781"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0088392"}],"foaf:name":[{"@language":"en","@value":"AZUMA Masayuki"},{"@language":"ja","@value":"東 雅之"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"徳島大学大学院ヘルスバイオサイエンス研究部口腔内科学分野"},{"@language":"en","@value":"Department of Oral Medicine, Institute of Health Biosciences, The University of Tokushima Graduate Faculty of Dentistry"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00290297"},{"@type":"EISSN","@value":"21850461"},{"@type":"NDL_BIB_ID","@value":"000000018403"},{"@type":"ISSN","@value":"00290297"},{"@type":"LISSN","@value":"00290297"},{"@type":"NCID","@value":"AN00189050"}],"prism:publicationName":[{"@language":"en","@value":"Journal of The Japanese Stomatological Society"},{"@language":"ja","@value":"日本口腔科学会雑誌"},{"@language":"en","@value":"J.Jpn.Stomatol.Soc"},{"@language":"ja","@value":"口腔科"},{"@language":"ja","@value":"口腔科学"},{"@language":"ja","@value":"口科誌"},{"@language":"en","@value":"J.Jpn.Stomatol.Soc."}],"dc:publisher":[{"@language":"en","@value":"Japanese Stomatological Society"},{"@language":"ja","@value":"特定非営利活動法人 日本口腔科学会"}],"prism:publicationDate":"2013","prism:volume":"62","prism:number":"4","prism:startingPage":"254","prism:endingPage":"261"},"reviewed":"true","url":[{"@id":"http://id.ndl.go.jp/bib/024942967"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I024942967"},{"@id":"https://search.jamas.or.jp/link/ui/2014097305"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Sj%C3%B6gren's%20syndrome","dc:title":"Sjögren's syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=cepharanthin","dc:title":"cepharanthin"},{"@id":"https://cir.nii.ac.jp/all?q=salivary%20gland%20acinar%20cell","dc:title":"salivary gland acinar cell"},{"@id":"https://cir.nii.ac.jp/all?q=Sj%C3%B6gren%E7%97%87%E5%80%99%E7%BE%A4","dc:title":"Sjögren症候群"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%BB%E3%83%95%E3%82%A1%E3%83%A9%E3%83%B3%E3%83%81%E3%83%B3","dc:title":"セファランチン"},{"@id":"https://cir.nii.ac.jp/all?q=%E5%94%BE%E6%B6%B2%E8%85%BA%E8%85%BA%E6%88%BF%E7%B4%B0%E8%83%9E","dc:title":"唾液腺腺房細胞"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782223693696","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24659896"},{"@type":"JGN","@value":"JP24659896"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659896/"}],"notation":[{"@language":"ja","@value":"口腔扁平苔癬に対する新規疾患病因論とそれに基づく治療戦略"},{"@language":"en","@value":"A novel histopathology of oral lichen plans and its therapeutic strategy"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257130171264","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23390464"},{"@type":"JGN","@value":"JP23390464"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390464/"}],"notation":[{"@language":"ja","@value":"シェーグレン症候群に対する病期対応型テーラーメード医療の構築"},{"@language":"en","@value":"Establishment of tailor-made therapy corresponding to the disease stage of Sjogren's syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257208554624","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24792223"},{"@type":"JGN","@value":"JP24792223"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792223/"}],"notation":[{"@language":"ja","@value":"加齢による唾液腺機能低下に対するアンチエイジング療法の構築"},{"@language":"en","@value":"Construction of the anti-aging therapy for the salivary gland functional decline by the aging"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257208557568","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24792226"},{"@type":"JGN","@value":"JP24792226"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792226/"}],"notation":[{"@language":"ja","@value":"抗ＴＮＦ療法による唾液腺機能再生医療の構築"},{"@language":"en","@value":"Salivary gland regeneration by anti-TNF regents"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1002442868"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I024942967"},{"@type":"CIA","@value":"130004781800"},{"@type":"KAKEN","@value":"PRODUCT-14799553"},{"@type":"KAKEN","@value":"PRODUCT-13961184"},{"@type":"KAKEN","@value":"PRODUCT-13961242"},{"@type":"KAKEN","@value":"PRODUCT-14890274"},{"@type":"KAKEN","@value":"PRODUCT-14890311"}]}