{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206477972736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1271/bbb.90910"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10688851"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/10688851"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I10688851"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.1271/bbb.90910"}},{"identifier":{"@type":"PMID","@value":"20460732"}},{"identifier":{"@type":"NAID","@value":"10027555168"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2010294638"}}],"dc:title":[{"@language":"en","@value":"Suppression of CD74 Expression and Helicobacter pylori Adhesion by Auraptene Targeting Serum Starvation-Activated ERK1/2 in NCI-N87 Gastric Carcinoma Cells"},{"@value":"Suppression of CD74 Expression and<i>Helicobacter pylori</i>Adhesion by Auraptene Targeting Serum Starvation-Activated ERK1/2 in NCI-N87 Gastric Carcinoma Cells"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<I>Helicobacter pylori</I> (<I>H. pylori</I>) is a major human pathogen and plays a central role in chronic gastritis and gastric cancer. Since the adhesion of <I>H. pylori</I> to the human gastric epithelium is the initial and critical step of its infection, anti-<I>H. pylori</I> adhesion agents may be effective for the prevention and therapy of <I>H. pylori</I>-associated diseases. CD74 has recently been identified as a new receptor for <I>H. pylori</I> urease, and we have previously reported that several citrus components strongly suppressed CD74 expression in NCI-N87 gastric carcinoma cells. We found in this present study that auraptene (citrus coumarin) disrupted serum starvation-induced extracellular signaling-regulated kinase (ERK) 1/2 activation and attenuated <I>H. pylori</I> adhesion and IL-8 production in a co-culture system. In addition, the knockdown of CD74 expression led to a significant decrease of <I>H. pylori</I> adhesion, but unexpectedly increased IL-8 production. However, PD98059 (a MEK1/2 inhibitor) dramatically down-regulated this cytokine, suggesting MEK/ERK-dependent IL-8 production. Our results suggest that auraptene suppressed <I>H. pylori</I> adhesion and resulting chemokine production by disrupting ERK1/2 activation."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001206477972738","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000018474182"}],"foaf:name":[{"@language":"en","@value":"SEKIGUCHI Hirotaka"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751156973440","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00168535"},{"@type":"NRID","@value":"1000000168535"},{"@type":"ORCID","@value":"0000-0001-7109-8568"},{"@type":"NDL_AUTHOR_ID","@value":"001229749"},{"@type":"CINII_AUTHOR_ID","@value":"DA18549647"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA18549647#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA18549647"},{"@type":"NRID","@value":"9000413949112"},{"@type":"NRID","@value":"9000020851014"},{"@type":"NRID","@value":"9000408426227"},{"@type":"NRID","@value":"9000020687218"},{"@type":"NRID","@value":"9000020802140"},{"@type":"NRID","@value":"9000405687347"},{"@type":"NRID","@value":"9000020711489"},{"@type":"NRID","@value":"9000004415958"},{"@type":"NRID","@value":"9000018473129"},{"@type":"NRID","@value":"9000020883741"},{"@type":"NRID","@value":"9000024205705"},{"@type":"NRID","@value":"9000376923591"},{"@type":"NRID","@value":"9000019089735"},{"@type":"NRID","@value":"9000021003697"},{"@type":"NRID","@value":"9000404101357"},{"@type":"NRID","@value":"9000261671029"},{"@type":"NRID","@value":"9000351064958"},{"@type":"NRID","@value":"9000362190105"},{"@type":"NRID","@value":"9000018278057"},{"@type":"NRID","@value":"9000304623592"},{"@type":"NRID","@value":"9000414940608"},{"@type":"NRID","@value":"9000327104925"},{"@type":"NRID","@value":"9000018474240"},{"@type":"NRID","@value":"9000404530371"},{"@type":"NRID","@value":"9000261040102"},{"@type":"NRID","@value":"9000020681388"},{"@type":"NRID","@value":"9000274300764"},{"@type":"NRID","@value":"9000241671176"},{"@type":"NRID","@value":"9000337092018"},{"@type":"NRID","@value":"9000018474183"},{"@type":"NRID","@value":"9000415346094"},{"@type":"NRID","@value":"9000107394740"},{"@type":"NRID","@value":"9000024152606"},{"@type":"NRID","@value":"9000411771448"},{"@type":"NRID","@value":"9000345337827"},{"@type":"NRID","@value":"9000311776592"},{"@type":"NRID","@value":"9000021127140"},{"@type":"NRID","@value":"9000408915549"},{"@type":"NRID","@value":"9000312733182"},{"@type":"NRID","@value":"9000409781432"},{"@type":"NRID","@value":"9000370759249"},{"@type":"NRID","@value":"9000411803351"},{"@type":"NRID","@value":"9000412315367"},{"@type":"NRID","@value":"9000020789319"},{"@type":"NRID","@value":"9000023269249"},{"@type":"NRID","@value":"9000020880984"},{"@type":"NRID","@value":"9000409179571"},{"@type":"NRID","@value":"9000402941936"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0013123"}],"foaf:name":[{"@language":"en","@value":"IRIE Kazuhiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326205883904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10271412"},{"@type":"NRID","@value":"1000010271412"},{"@type":"NRID","@value":"9000238323642"},{"@type":"NRID","@value":"9000237871336"},{"@type":"NRID","@value":"9000020710087"},{"@type":"NRID","@value":"9000021872602"},{"@type":"NRID","@value":"9000261671151"},{"@type":"NRID","@value":"9000018473130"},{"@type":"NRID","@value":"9000024205684"},{"@type":"NRID","@value":"9000415423255"},{"@type":"NRID","@value":"9000021896538"},{"@type":"NRID","@value":"9000022032802"},{"@type":"NRID","@value":"9000404101358"},{"@type":"NRID","@value":"9000018469807"},{"@type":"NRID","@value":"9000018470336"},{"@type":"NRID","@value":"9000259862175"},{"@type":"NRID","@value":"9000001863950"},{"@type":"NRID","@value":"9000016525642"},{"@type":"NRID","@value":"9000283587822"},{"@type":"NRID","@value":"9000283423074"},{"@type":"NRID","@value":"9000018474241"},{"@type":"NRID","@value":"9000336385872"},{"@type":"NRID","@value":"9000007040945"},{"@type":"NRID","@value":"9000283154495"},{"@type":"NRID","@value":"9000021814811"},{"@type":"NRID","@value":"9000018474184"},{"@type":"NRID","@value":"9000412546953"},{"@type":"NRID","@value":"9000024152628"},{"@type":"NRID","@value":"9000347361573"},{"@type":"NRID","@value":"9000415311390"},{"@type":"NRID","@value":"9000409781433"},{"@type":"NRID","@value":"9000383075256"},{"@type":"NRID","@value":"9000412546911"},{"@type":"NRID","@value":"9000254710910"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sftnetts"}],"foaf:name":[{"@language":"en","@value":"MURAKAMI Akira"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09168451"},{"@type":"EISSN","@value":"13476947"},{"@type":"NDL_BIB_ID","@value":"000000151899"},{"@type":"ISSN","@value":"09168451"},{"@type":"LISSN","@value":"09168451"},{"@type":"NCID","@value":"AA10824164"}],"prism:publicationName":[{"@language":"en","@value":"Bioscience, Biotechnology, and Biochemistry"},{"@language":"ja","@value":"Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ"},{"@language":"en","@value":"Biosci. Biotechnol. Biochem."},{"@language":"en","@value":"Bioscience, Biotechnology, and Biochemistry"},{"@language":"ja","@value":"Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Bioscience, Biotechnology, and Agrochemistry"},{"@language":"ja","@value":"公益社団法人 日本農芸化学会"}],"prism:publicationDate":"2010","prism:volume":"74","prism:number":"5","prism:startingPage":"1018","prism:endingPage":"1024"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/10688851"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I10688851"},{"@id":"http://www.tandfonline.com/doi/pdf/10.1271/bbb.90910"},{"@id":"https://search.jamas.or.jp/link/ui/2010294638"}],"availableAt":"2010","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%3CI%3EHelicobacter%20pylori%3C/I%3E","dc:title":"<I>Helicobacter pylori</I>"},{"@id":"https://cir.nii.ac.jp/all?q=CD74","dc:title":"CD74"},{"@id":"https://cir.nii.ac.jp/all?q=adhesion","dc:title":"adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=IL-8","dc:title":"IL-8"},{"@id":"https://cir.nii.ac.jp/all?q=auraptene","dc:title":"auraptene"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144490746368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detection of epidermal growth factor receptor in the serum of gastric carcinoma patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618741835008","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Translocation of\n            <i>Helicobacter pylori</i>\n            CagA into Gastric Epithelial Cells by Type IV Secretion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618778465920","@type":"Article","relationType":["references","cites"],"jpcoar:relatedTitle":[{"@value":"Auraptene, a Citrus Coumarin, Inhibits 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Tyrosine Kinase-Dependent Transcription of Interleukin-8 in Gastric Epithelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369104585856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843390597632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MIF regulates innate immune responses through modulation of Toll-like receptor 4"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843394428032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/<i>neu</i>Oncogene"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844105744256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845473575168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319121827712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>-induced Expression of Interleukin-8 and Cyclooxygenase-2 in AGS Gastric Epithelial Cells: Mediation by Nuclear Factor-?B"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319239396352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>\n                    -Induced IL-8 Production by Gastric Epithelial Cells Up-Regulates CD74 Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319933206784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Helicobacter pylori</i>\n                    Infection and the Risk of Gastric Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321040400256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of NF-κB and AP-1 on Helicobater pylori-Induced IL-8 Expression in AGS Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794159213440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>EGFR</i>\n                    Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794485617280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophage Migration Inhibitory Factor and Interleukin-8 Produced by Gastric Epithelial Cells during\n            <i>Helicobacter 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Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680152575872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Chemistry of Ether. 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