{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001206478281856.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1271/bbb.110436"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"023331035"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/023331035"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I023331035"}},{"identifier":{"@type":"URI","@value":"http://www.tandfonline.com/doi/pdf/10.1271/bbb.110436"}},{"identifier":{"@type":"NAID","@value":"10030396583"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2012139877"}}],"dc:title":[{"@language":"en","@value":"Identification of Acvr2a as a Th17 Cell-Specific Gene Induced during Th17 Differentiation"},{"@value":"Identification of<i>Acvr2a</i>as a Th17 Cell-Specific Gene Induced during Th17 Differentiation"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"IL-17-producing T lymphocytes have been found to comprise a distinct lineage of T helper cells (Th17 cells) that are major causes of autoimmune diseases such as EAE, RA, and IBD. In this study, we found that activin receptor type-2A (Acvr2a) is a gene induced during the differentiation of this effector cell lineage as compared with naïve T cells. The transcript of Acvr2a was not induced in Th1 and Th2 cells, and both TGF-β and IL-6 were required for the induction of <I>Acvr2a</I>. When the differentiation of Th17 cells was inhibited by all tarans retinoic acid (ATRA) which induces regulatory T cell (Treg) differentiation under Th17 differentiation conditions, expression of Acvr2a was also inhibited. Hence we propose that Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001206478281859","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019089670"}],"foaf:name":[{"@language":"en","@value":"IHN Hyun-ju"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Applied Life Science, PMBBRC, Gyeongsang National University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206478281862","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019089671"}],"foaf:name":[{"@language":"en","@value":"KIM Dong Hyeok"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Applied Life Science, PMBBRC, Gyeongsang National University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206478281857","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019089674"}],"foaf:name":[{"@language":"en","@value":"MOON Chaerin"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Applied Life Science, PMBBRC, Gyeongsang National University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206478281856","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019089675"}],"foaf:name":[{"@language":"en","@value":"CHUNG Jin Woong"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Biological Science, Dong-A University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206478281861","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019089673"}],"foaf:name":[{"@language":"en","@value":"OH Sang-Seok"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Applied Life Science, PMBBRC, Gyeongsang National University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206478281860","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019089676"}],"foaf:name":[{"@language":"en","@value":"SONG Hyunkeun"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Anatomy and Tumor Immunology, Inje University College of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001206478281858","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019089677"}],"foaf:name":[{"@language":"en","@value":"KIM Kwang Dong"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Division of Applied Life Science, PMBBRC, Gyeongsang National University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09168451"},{"@type":"EISSN","@value":"13476947"},{"@type":"NDL_BIB_ID","@value":"000000151899"},{"@type":"ISSN","@value":"09168451"},{"@type":"LISSN","@value":"09168451"},{"@type":"NCID","@value":"AA10824164"}],"prism:publicationName":[{"@language":"en","@value":"Bioscience, Biotechnology, and Biochemistry"},{"@language":"ja","@value":"Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ"},{"@language":"en","@value":"Biosci. Biotechnol. Biochem."},{"@language":"en","@value":"Bioscience, Biotechnology, and Biochemistry"},{"@language":"ja","@value":"Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ"}],"dc:publisher":[{"@language":"en","@value":"Japan Society for Bioscience, Biotechnology, and Agrochemistry"},{"@language":"ja","@value":"公益社団法人 日本農芸化学会"}],"prism:publicationDate":"2011","prism:volume":"75","prism:number":"11","prism:startingPage":"2138","prism:endingPage":"2141"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/023331035"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I023331035"},{"@id":"http://www.tandfonline.com/doi/pdf/10.1271/bbb.110436"},{"@id":"https://search.jamas.or.jp/link/ui/2012139877"}],"availableAt":"2011","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=helper%20type%2017%20T%20cell%20(Th17)","dc:title":"helper type 17 T cell 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