Purpose: The purpose of this study was to clarify the influence of the use of denture adhesive containing alcohol (home reliner) on breath alcohol concentration (BAC) through in vitro and in vivo experiments.
Methods: In the in vitro study, five materials—three kinds of denture adhesives and two tissue conditioners—were examined. The diffusion of alcohol odor was measured over time using a semiconductor odor sensor when each specimen was placed in a semi-closed space simulating the oral cavity. In the in vivo study, healthy young subjects were asked to wear the palatal plates lined with each denture adhesive or tissue conditioner, and the BAC was measured over time with an alcohol detector. One denture adhesive and one tissue conditioner were examined. Furthermore, the palatal plate was removed 5 minutes later after wearing and the BAC after removal was also measured.
Results: In the in vitro study, the odor intensity remained without much reduction one hour later and increased in proportion to the area exposed to the air. In the in vivo study, the BAC was the highest immediately after wearing, and exceeded 0.15 mg/L, which is the threshold for drunken driving, during 5 minutes after wearing. However, the BAC decreased with time, and was 0 mg/L 30 minutes later. The BAC in the lining with denture adhesive was significantly higher than that of tissue conditioner. Although the BAC transiently increased after removing the palatal plate, it became 0 mg/L 10 minutes later.
Conclusion: The use of denture adhesive containing alcohol influenced the BAC. It is suggested that the appropriate use and removal of the denture could reduce the increase of BAC.
"},{"@language":"ja","@value":"目的：本研究では，アルコール含有義歯安定剤であるホームリライナーの使用が呼気中アルコール濃度（Breath alcohol concentration: BAC）へ与える影響を明らかにすることを目的とした．
方法：義歯安定剤3種類および粘膜調整材2種類において，口腔内を模した準閉鎖空間内でのアルコール臭の拡散実験を行い，におい強度の経時的変化の検討および露出面積による差の比較を行った．また，健常有歯顎者に義歯安定剤を使用した口蓋床を装着し，アルコール検知器でBACの測定を行った．粘膜調整材に対しても同様の方法でBAC を測定し義歯安定剤の結果と比較した．更に，装着5分後に撤去し，撤去後のBACを測定した．
結果：拡散実験では，義歯安定剤のにおい強度は露出面積に比例し，増加した．健常有歯顎者に対するBAC測定では，装着直後が最も高く，装着5分後までは酒気帯び運転の基準となる0.15 mg/Lを上回っていたが，経時的に減少し，装着30分後で0 mg/L となった．また，義歯安定剤のBACは粘膜調整材と比較して有意に高い値を示した．口蓋床撤去時には，一時的な増加は認めるが撤去10分後に0 mg/Lとなった．
結論：義歯安定剤はアルコールを放出し，BACに影響を与える可能性があるが，使用法の遵守または口腔外への撤去によりその影響を小さくできることが明らかとなった．
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