書誌事項
- タイトル別名
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- Dynamic Range Extension of Eukaryotic Chemotaxis through the Regulation of G Protein Localization
- サンリョウタイ Gタンパクシツ ノ キョクザイセイギョ オ カイシタ ソウカセイ レンジ ノ カクチョウ キコウ
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説明
<p>Various types of cells display chemotaxis in a wide-range of attractant concentration gradient. However, mechanisms underlying the wide-range sensing are not fully understood. We have identified a novel regulator of heterotrimeric G proteins, G protein interacting protein 1 (Gip1), that extends a dynamic range of Dictyostelium chemotaxis. Our studies revealed that the Gip1-dependent spatial regulation of G protein contributed to the dynamic range extension. This differs from commonly known mechanisms including adaptation associated with the chemical modification of receptor. Higher eukaryotic cells, such as neutrophils, may adopt similar mechanism using Gip1 homologs.</p>
収録刊行物
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- 生物物理
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生物物理 58 (5), 237-240, 2018
一般社団法人 日本生物物理学会
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詳細情報 詳細情報について
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- CRID
- 1390001288073976064
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- NII論文ID
- 130007493735
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- NII書誌ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL書誌ID
- 029309599
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可