Early suspicion of disseminated cutaneous mucormycosis leading to successful treatment after bone marrow transplantation in a patient with acute myeloid leukemia

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  • 早期の想定が功を奏した急性骨髄性白血病の骨髄移植後に発症した播種性皮膚ムコール感染症例

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Abstract

<p>Mucormycosis can be life-threatening, especially when the infection is disseminated. Early diagnosis is essential, although a lack of specific biomarkers renders this difficult. We present the case of a patient with acute myeloid leukemia with disseminated cutaneous mucormycosis treated successfully. We initiated liposomal amphotericin B treatment before a definitive diagnosis was made, basing the decision on the presence of multiple risk factors for mucormycosis, such as severe neutropenia and monocytopenia due to bone marrow suppression and exacerbation of the primary disease, malignant hematological disease, bone marrow transplantation, excess iron due to blood transfusion, and precedent initiation of voriconazole. The skin lesions improved without surgical resection. This case illustrates that understanding the risk factors for mucormycosis and prompt administration of appropriate therapy are essential for its treatment in patients with hematological malignancies.</p>

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