[Updated on Apr. 18] Integration of CiNii Articles into CiNii Research

Extranodal NK/T-cell Lymphoma Mimicking Granulomatous Myositis

  • Kawaguchi Norihiko
    Department of Neurology, Tohoku Medical and Pharmaceutical University, Japan
  • Izumi Rumiko
    Department of Neurology, Tohoku University School of Medicine, Japan
  • Kobayashi Masahiro
    Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Japan
  • Tateyama Maki
    Department of Neurology, Tohoku University School of Medicine, Japan Department of Neurology, Iwate National Hospital, Japan
  • Suzuki Naoki
    Department of Neurology, Tohoku University School of Medicine, Japan
  • Fujishima Fumiyoshi
    Department of Pathology, Tohoku University Hospital, Japan
  • Fujimori Juichi
    Department of Neurology, Tohoku Medical and Pharmaceutical University, Japan
  • Aoki Masashi
    Department of Neurology, Tohoku University School of Medicine, Japan
  • Nakashima Ichiro
    Department of Neurology, Tohoku Medical and Pharmaceutical University, Japan

Abstract

<p>Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive non-Hodgkin lymphoma that typically develops in the upper aerodigestive tract. We encountered an ENKTL patient who presented with generalized muscle weakness with eyelid swelling, diplopia, and facial edema. A muscle biopsy revealed lymphocytic infiltration without significant atypia; some lymphocytes formed granuloma-like structures. Although the initial response to steroids was encouraging, an ulcerative eruption appeared in the thigh, and a skin biopsy revealed lymphocytes with atypia. A re-analysis of the muscle biopsy with additional immunohistochemistry revealed neoplastic NK/T lymphocytes in the granulomatous structures. Our case highlights the significance of re-evaluating muscle biopsy specimens in cases of atypical myositis. </p>

Journal

  • Internal Medicine

    Internal Medicine 58 (2), 277-282, 2019-01-15

    The Japanese Society of Internal Medicine

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