Highlighted Paper selected by Editor-in-Chief : T₂ Relaxation Study to Evaluate the Crystalline State of Indomethacin Containing Solid Dispersions Using Time-Domain NMR
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- Okada Kotaro
- Department of Pharmaceutical Technology, Graduate School of Medical and Pharmaceutical Science, University of Toyama
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- Hirai Daijiro
- Nichi-Iko Pharmaceutical Co., Ltd., Formulation Development Department
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- Hayashi Yoshihiro
- Department of Pharmaceutical Technology, Graduate School of Medical and Pharmaceutical Science, University of Toyama Nichi-Iko Pharmaceutical Co., Ltd., Formulation Development Department
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- Kumada Shungo
- Nichi-Iko Pharmaceutical Co., Ltd., Formulation Development Department
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- Kosugi Atsushi
- Nichi-Iko Pharmaceutical Co., Ltd., Formulation Development Department
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- Onuki Yoshinori
- Department of Pharmaceutical Technology, Graduate School of Medical and Pharmaceutical Science, University of Toyama
書誌事項
- タイトル別名
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- <i>T</i><sub>2</sub> Relaxation Study to Evaluate the Crystalline State of Indomethacin Containing Solid Dispersions Using Time-Domain NMR
- T 2 Relaxation study to evaluate the crystalline state of indomethacin containing solid dispersions using time-domain NMR
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説明
<p>The aim of this study was to demonstrate the usefulness of T2 measurements conducted with a time-domain NMR (TD-NMR) for the characterization of active pharmaceutical ingredients (APIs) containing solid dosage forms. A solid dispersion (SD) and a physical mixture (PM) consisting of indomethacin (IMC) and polyvinylpyrrolidone (PVP) were prepared at different weight ratios as test samples, and then their T2 relaxation curves were measured by TD-NMR. The T2 relaxation curve of IMC was quite different from that of PVP by nature. T2 values of the SD and PM samples became gradually shortened with increasing IMC content. No difference in T2 relaxation curves was observed between SD and PM. By analyzing the T2 relaxation curves in detail, we succeeded in precisely quantifying the IMC contents incorporated in the samples. Next, this study evaluated the T2 relaxation curves of amorphous and crystalline states of powdered IMC. T2 relaxation rate of crystalline IMC was slightly but significantly higher than that of amorphous IMC, proving that the T2 measurement was sensitive enough to detect these differences. Finally, a thermal stress was imposed on SD and PM samples at 60°C for 7 d, and then an amorphous-to-crystalline transformation occurred in IMC in the PM sample and was successfully monitored by T2 measurement. We believe that T2 measurement by TD-NMR is a promising analysis for the characterization of APIs in solid dosage forms, including SD-based pharmaceuticals.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 67 (6), 580-586, 2019-06-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001288142900608
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- NII論文ID
- 130007657420
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 029698558
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- PubMed
- 31155564
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可