Impact of <i>PSCA</i> Polymorphisms on the Risk of Duodenal Ulcer

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  • Usui Yoshiaki
    Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceuticals Sciences
  • Matsuo Keitaro
    Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Department of Epidemiology, Nagoya University Graduate School of Medicine
  • Oze Isao
    Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center
  • Ugai Tomotaka
    Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center
  • Koyanagi Yuriko
    Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center
  • Maeda Yoshinobu
    Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceuticals Sciences
  • Ito Hidemi
    Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine
  • Hishida Asahi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Takeuchi Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Tamura Takashi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Tsukamoto Mineko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Kadomatsu Yuka
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Hara Megumi
    Department of Preventive Medicine, Faculty of Medicine, Saga University
  • Nishida Yuichiro
    Department of Preventive Medicine, Faculty of Medicine, Saga University
  • Shimoshikiryo Ippei
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Takezaki Toshiro
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Ozaki Etsuko
    Department of Epidemiology for Community Health and Medicine Kyoto Prefectural University of Medicine
  • Matsui Daisuke
    Department of Epidemiology for Community Health and Medicine Kyoto Prefectural University of Medicine
  • Watanabe Isao
    Department of Epidemiology for Community Health and Medicine Kyoto Prefectural University of Medicine
  • Suzuki Sadao
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Watanabe Miki
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Nakagawa-Senda Hiroko
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Mikami Haruo
    Cancer Prevention Center, Chiba Cancer Center Research Institute
  • Nakamura Yohko
    Cancer Prevention Center, Chiba Cancer Center Research Institute
  • Arisawa Kokichi
    Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Uemura Hirokazu
    Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Kuriki Kiyonori
    Laboratory of Public Health, University of Shizuoka
  • Takashima Naoyuki
    Department of Public Health, Faculty of Medicine, Kindai University
  • Kadota Aya
    Department of Public Health, Shiga University of Medical Science
  • Ikezaki Hiroaki
    Department of General Internal Medicine, Kyushu University Hospital
  • Murata Masayuki
    Department of General Internal Medicine, Kyushu University Hospital
  • Nakatochi Masahiro
    Department of Nursing, Nagoya University Graduate School of Medicine
  • Momozawa Yukihide
    Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
  • Kubo Michiaki
    Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
  • Wakai Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine

書誌事項

公開日
2021-01-05
資源種別
journal article
DOI
  • 10.2188/jea.je20190184
公開者
日本疫学会

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説明

<p>Background: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population.</p><p>Methods: Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU.</p><p>Results: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; P = 2.28 × 10−6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs.</p><p>Conclusions: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.</p>

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