Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study

DOI 機関リポジトリ Web Site PubMed 被引用文献2件 参考文献49件 オープンアクセス
  • Iwase Madoka
    Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute Department of Surgical Oncology, Nagoya University Graduate School of Medicine
  • Matsuo Keitaro
    Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine
  • Nakatochi Masahiro
    Department of Nursing, Nagoya University Graduate School of Medicine
  • Oze Isao
    Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
  • Ito Hidemi
    Division of Cancer Information and Control, Aichi Cancer Center Research Institute Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine
  • Koyanagi Yuriko
    Division of Cancer Information and Control, Aichi Cancer Center Research Institute
  • Ugai Tomotaka
    Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
  • Kasugai Yumiko
    Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
  • Hishida Asahi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Takeuchi Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Okada Rieko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Kubo Yoko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Shimanoe Chisato
    Clinical Research Center, Saga University Hospital
  • Tanaka Keitaro
    Department of Preventive Medicine, Faculty of Medicine, Saga University
  • Ikezaki Hiroaki
    Department of General Internal Medicine, Kyushu University Hospital
  • Murata Masayuki
    Department of General Internal Medicine, Kyushu University Hospital
  • Takezaki Toshiro
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Nishimoto Daisaku
    School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Kuriyama Nagato
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
  • Ozaki Etsuko
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
  • Suzuki Sadao
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Watanabe Miki
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Mikami Haruo
    Cancer Prevention Center, Chiba Cancer Center Research Institute
  • Nakamura Yohko
    Cancer Prevention Center, Chiba Cancer Center Research Institute
  • Uemura Hirokazu
    Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Katsuura-Kamano Sakurako
    Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School
  • Kuriki Kiyonori
    Laboratory of Public Health, University of Shizuoka
  • Kita Yoshikuni
    Faculty of Nursing Science, Tsuruga Nursing University
  • Takashima Naoyuki
    Department of Public Health, Faculty of Medicine, Kindai University
  • Nagino Masato
    Department of Surgical Oncology, Nagoya University Graduate School of Medicine
  • Momozawa Yukihide
    Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
  • Kubo Michiaki
    RIKEN Center for Integrative Medical Sciences
  • Wakai Kenji
    Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine

書誌事項

公開日
2021-03-05
資源種別
journal article
DOI
  • 10.2188/jea.je20190296
公開者
日本疫学会

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説明

<p>Background: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities.</p><p>Methods: We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20), and change in BMI (BMI change), among 11,586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models.</p><p>Results: We found a significant association (P < 0.05/282 = 1.77 × 10−4) between BMI and 11 polymorphisms in or near FTO, BDNF, TMEM18, HS6ST3, and BORCS7. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on FTO were associated with all BMI traits, whereas those on TMEM18 and HS6SR3 were only associated with BMI at 20. The association of FTO loci with BMI remained, even after additional adjustment for dietary energy intake.</p><p>Conclusions: Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.</p>

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