Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study
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- Kihara Tomomi
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba
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- Yamagishi Kazumasa
- Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba
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- Honda Kazufumi
- Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute
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- Ikeda Ai
- Department of Public Health, Juntendo University Graduate School of Medicine
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- Yatsuya Hiroshi
- Department of Public Health, Fujita Health University School of Medicine
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- Saito Isao
- Department of Public Health and Epidemiology, Faculty of Medicine, Oita University
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- Kokubo Yoshihiro
- Department of Preventive Cardiology, National Cerebral and Cardiovascular Center
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- Yamaji Taiki
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
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- Shimazu Taichi
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
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- Sawada Norie
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
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- Iwasaki Motoki
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
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- Iso Hiroyasu
- Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba
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- Tsugane Shoichiro
- Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
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<p>Aim: The fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of cardiovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apolipoprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction. </p><p>Methods: We measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls. </p><p>Results: ApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% CI, 1.26–6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% CI, 0.91–4.97) or drinking only (OR=2.11; 0.91–4.89), and the multivariable OR was 1.20 (95% CI, 0.41–3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associated with the risk of myocardial infarction. </p><p>Conclusions: Our nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction. </p>
収録刊行物
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 28 (5), 483-490, 2021-05-01
一般社団法人 日本動脈硬化学会
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詳細情報
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- CRID
- 1390006432293518976
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- NII論文ID
- 130008032936
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- NII書誌ID
- AA11018976
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- ISSN
- 18803873
- 13403478
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- HANDLE
- 2241/0002001142
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- PubMed
- 32863295
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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