Women With Osteoarthritis Are at Increased Risk of Ischemic Stroke: A Population-Based Cohort Study

DOI Web Site PubMed 47 References
  • Chan Po-Chi
    Department of Neurology, Show Chwan Memorial Hospital
  • Chang Ko-Shih
    Department of Cardiology, Yuan Rung Hospital
  • Hsu Chung Y.
    Graduate Institute of Clinical Medical Science, China Medical University
  • Chang Wei-Lun
    Department of Neurology, Show Chwan Memorial Hospital
  • Yeh Chung-Hsin
    Department of Nursing, College of Nursing and Health Sciences, Da-Yeh University Department of Neurology, Yuan Sheng Hospital
  • Tsay Shiow-Luan
    Department of Nursing, College of Nursing and Health Sciences, Da-Yeh University
  • Hsu Min-Hsien
    Department of Neurology, Show Chwan Memorial Hospital
  • Mou Chih-Hsin
    Management Office for Health Data, China Medical University Hospital
  • Tsai Min-Tein
    Department of Neurology, Yuan Sheng Hospital
  • Sung Fung-Chang
    Management Office for Health Data, China Medical University Hospital Department of Health Services Administration, China Medical University College of Public Health Department of Food Nutrition and Health Biotechnology, Asia University

Bibliographic Information

Published
2021-12-05
Resource Type
journal article
DOI
  • 10.2188/jea.je20200042
Publisher
Japan Epidemiological Association

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<p>Background: Osteoarthritis (OA) is more prevalent in women with age. Comorbidities are prevalent in OA patients. In this study, we conducted a follow-up study to evaluate whether women with OA are at an increased risk of ischemic stroke using insurance claims data of Taiwan.</p><p>Methods: We identified 13,520 women with OA aged 20–99 newly diagnosed in 2000–2006 and 27,033 women without OA for comparison, frequency matched by age and diagnosis date. Women with baseline history of hypertension and other disorders associated with stroke were excluded for this study. Incident ischemic stroke was assessed by the end of 2013. A nested case-control analysis was used to identify factors associated with the stroke in the OA cohort.</p><p>Results: The incidence rate of ischemic stroke in the OA cohort was 1.5-fold greater than that in comparisons (1.93 versus 1.26 per 1,000 person-years), with an adjusted hazard ratio of 1.34 (95% confidence interval [CI], 1.09–1.66). The nested case-control analysis showed that stroke cases were twice as likely to develop hypertension during the follow-up period than controls without stroke. The ischemic stroke risk was significantly associated with hypertension (odds ratio [OR] 1.84; 95% CI, 1.37–2.46) and atrial fibrillation (OR 2.25; 95% CI, 1.24–4.09). Ischemic stroke was not associated with the use of non-steroidal anti-inflammatory drugs or aspirin.</p><p>Conclusion: Women with OA are at an elevated risk of ischemic stroke. A close monitoring of hypertension, atrial fibrillation, and other stroke related comorbidities is required for stroke prevention for OA patients.</p>

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