Is oral food challenge useful to avoid complete elimination in Japanese patients diagnosed with or suspected of having IgE-dependent hen's egg allergy?
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- Murai Hiroki
- Department of Pediatrics, University of Fukui
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- Irahara Makoto
- Allergy Center, National Center for Child Health and Development
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- Sugimoto Mayumi
- Department of Pediatrics, Tokushima University Hospital
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- Takaoka Yuri
- Department of Pediatrics, Osaka Habikino Medical Center
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- Takahashi Kyohei
- Department of Pediatrics, National Hospital Organization Sagamihara National Hospital
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- Wada Takuya
- Department of Pediatrics, Faculty of Medicine, University of Toyama
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- Yamamoto-Hanada Kiwako
- Allergy Center, National Center for Child Health and Development
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- Okafuji Ikuo
- Department of Pediatrics, Kobe City Medical Center General Hospital
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- Futamura Masaki
- Department of Pediatrics, National Hospital Organization Nagoya Medical Center
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- Yamada Yoshiyuki
- Department of Allergy and Immunology, Gunma Children's Medical Center Department of Pediatrics, Tokai University School of Medicine
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- Ebisawa Motohiro
- Clinical Research Center for Allergology and Rheumatology, National Hospital Organization Sagamihara National Hospital
Bibliographic Information
- Other Title
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- CQ3 日本のIgE依存性鶏卵アレルギー患者もしくはその疑いのある者において,食物経口負荷試験は完全除去回避に有用か?
Description
<p>Background: IgE-mediated egg allergy is a common food allergy worldwide. Patients with egg allergy are known to easily achieve tolerance compared to other allergens such as nuts. Oral food challenge (OFC) is often performed on patients diagnosed with or suspected of having IgE-mediated food allergy, but whether hen's egg OFC is useful in IgE-dependent egg allergy patients to avoid complete elimination remains unknown.</p><p>Methods: We identified articles in which OFCs were performed in Japanese patients diagnosed with or suspected of having IgE-mediated egg allergy. We evaluated whether the OFCs were useful to avoid the complete elimination of eggs by assessing the following: (1) the number of patients who could avoid complete elimination; (2) the number of patients who experienced serious adverse events (SAEs); or (3) adverse events (AEs); (4) improvement in quality of life (QOL); and (5) immunological changes.</p><p>Results: Fifty-nine articles were selected in the study; all the references were case series or case studies in which OFC was compared to pre-challenge conditions. The overall negative ratio against egg OFC was 62.7%, but an additional 71.9% of OFC-positive patients could take eggs when expanded to partial elimination. Of the 4,182 cases, 1,146 showed AEs in the OFC, and two cases reached an SAE. Two reports showed an improvement in QOL and immunological changes, although the evidence was weak.</p><p>Conclusions: OFCs against eggs may be useful to avoid complete elimination, but medical professionals should proceed with the test safely and carefully.</p>
Journal
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- Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
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Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 35 (5), 490-502, 2021-12-20
THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY
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Details 詳細情報について
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- CRID
- 1390008998107121152
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- NII Article ID
- 130008131193
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- ISSN
- 18822738
- 09142649
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed