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A Short History of the Hatching Enzyme Studies in Medaka(<Special Issue>Development of Medaka Biology in Japan-Part II)

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The studies on the hatching enzyme of the medaka, Oryzias latipes, have a history of about 50 years, which is only a half of whole history of the studies on the hatching enzyme in animals since the first conjecture of it in a lung fish in 1900. Medaka, however, has served as the material most intensively studied for the enzyme, and the studies have given invaluable information to establish some significant concepts in the field of developmental and cell biology as well as the hatching biology. In this essay, a history of the hatching enzyme studies in medaka is briefly described.



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