{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390010292494388480.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5551/jat.61960"}},{"identifier":{"@type":"PMID","@value":"33487620"}},{"identifier":{"@type":"DOI","@value":"10.5551/jat.er61960"}},{"identifier":{"@type":"PMID","@value":"37880136"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jat/30/12/30_ER61960/_pdf"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/jat/29/3/29_61960/_pdf"}},{"identifier":{"@type":"NAID","@value":"130008165681"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2023115970"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p><b>Aim:</b>To develop and validate a new risk prediction model for predicting the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in Japanese adults.        </p><p><b>Methods:</b> A total of 2,454 participants aged 40–84 years without a history of cardiovascular disease (CVD) were prospectively followed up for 24 years. An incident ASCVD event was defined as the first occurrence of coronary heart disease or atherothrombotic brain infarction. A Cox proportional hazards regression model was used to construct the prediction model. In addition, a simplified scoring system was translated from the developed prediction model. The model performance was evaluated using Harrell’s C statistics, a calibration plot with the Greenwood-Nam-D’Agostino test, and a bootstrap validation procedure.        </p><p><b>Results:</b> During a median of a 24-year follow-up, 270 participants experienced the first ASCVD event. The predictors of the ASCVD events in the multivariable Cox model included age, sex, systolic blood pressure, diabetes, serum high-density lipoprotein cholesterol, serum low-density lipoprotein cholesterol, proteinuria, smoking habits, and regular exercise. The developed models exhibited good discrimination with negligible evidence of overfitting (Harrell’s C statistics: 0.786 for the multivariable model and 0.789 for the simplified score) and good calibrations (the Greenwood-Nam-D’Agostino test:  <i>P</i>=0.29 for the multivariable model, 0.52 for the simplified score).        </p><p><b>Conclusion:</b> We constructed a risk prediction model for the development of ASCVD in Japanese adults. This prediction model exhibits great potential as a tool for predicting the risk of ASCVD in clinical practice by enabling the identification of specific risk factors for ASCVD in individual patients.        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Takanori"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276166700672","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70808659"},{"@type":"NRID","@value":"1000070808659"},{"@type":"ORCID","@value":"0000-0003-0811-1701"},{"@type":"CINII_AUTHOR_ID","@value":"DB00381353"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DB00381353#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDB00381353"},{"@type":"NRID","@value":"9000325830860"},{"@type":"NRID","@value":"9000345322476"},{"@type":"NRID","@value":"9000415087242"},{"@type":"NRID","@value":"9000415427852"},{"@type":"NRID","@value":"9000409646629"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sanmei.chen"}],"foaf:name":[{"@language":"en","@value":"Chen Sanmei"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department 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Toshiharu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University"},{"@language":"en","@value":"Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13403478"},{"@type":"EISSN","@value":"18803873"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Atherosclerosis and Thrombosis"},{"@language":"ja","@value":"Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ"},{"@language":"en","@value":"JAT"},{"@language":"en","@value":"J Atheroscler Thromb"},{"@language":"ja","@value":"Ｊ　Ａｔｈｅｒｏｓｃｌｅｒ　Ｔｈｒｏｍｂ"}],"dc:publisher":[{"@language":"en","@value":"Japan Atherosclerosis Society"},{"@language":"ja","@value":"一般社団法人 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