Gold Nanorod Mass-Probe to Trace the Biodistribution of Nanomaterials

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  • IWAIZAKO Kento
    Department of Chemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University
  • NIIDOME Yasuro
    Department of Chemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University Department of Science, Graduate School of Science and Engineering, Kagoshima University

Bibliographic Information

Other Title
  • ナノ材料の体内動態を明らかにする金ナノロッドマスプローブ
  • ナノ ザイリョウ ノ タイナイ ドウタイ オ アキラカ ニ スル キン ナノロッドマスプローブ
Published
2022-03-05
Resource Type
journal article
DOI
  • 10.2116/bunsekikagaku.71.153
Publisher
The Japan Society for Analytical Chemistry

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Description

<p>Gold nanorods were mixed in feed and fed to zebrafish. Imaging mass spectrometry (IMS) of gold ions, which desorbed from whole body sections, indicated the distribution of the nanorods in the living bodies. Soon after the feeding, the IMS indicated strong gold ion signals (m/z 197) at around the digestive organs. At 12 h after feeding, the signals were additionally found in the liver. At 24 h after feeding, the IMS of gold ions showed the signals in a few spots. Mass spectrometry of organs removed from the bodies indicated that the nanorods were accumulated in the liver and exhausted within 24 h after the feeding. The distribution of the gold nanorods could be traced for at least 24 h in a living body. It was shown that the gold nanorods could be a mass probe having a potential to evaluate risks of nanomaterials for living bodies.</p>

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 71 (3), 153-157, 2022-03-05

    The Japan Society for Analytical Chemistry

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