{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390011231093975296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.5136/lifesupport.33.52"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"031605759"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/031605759"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I031605759"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/lifesupport/33/2/33_52/_pdf"}},{"identifier":{"@type":"NAID","@value":"40022646787"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2021277489"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Evaluation of the Effects of the Changes in Flow Channel Deformation by Cyclic Loading on Blood Flow Characteristics in a Roller Pump Model"},{"@language":"ja","@value":"ローラポンプの繰り返し負荷による流路形状変化が血流特性に及ぼす影響の検討"},{"@language":"ja-Kana","@value":"ローラポンプ ノ クリカエシ フカ ニ ヨル リュウロ ケイジョウ ヘンカ ガ ケツリュウ トクセイ ニ オヨボス エイキョウ ノ ケントウ"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<p>Roller pumps are widely used as one of the cardiopulmonary bypasses during open-heart surgery. Hemolysis may cause acute kidney injury due to the changes in the tubing gap by the occlusion of roller pumps. In this study, we achieved the 3-D evaluation of the roller pump tubing gap for the first time by our originally developed visualization analysis. We examined the leak rate and the hemolysis under the 240-min circulatory support condition in a mock flow tester, and compared the tubing gap dimensions. As a result, the primary leak rate around 0.8 mL/min against 1 mH<sub>2</sub>O afterload significantly decreased after 60-min circulation, and there was no leak rate detected for 10 minutes measurement afterwards. The 3-D tubing gaps indicated that the subsidiary opening width at the short-axis edge decreased by more flattening shapes. Moreover, plasma free hemoglobin levels showed a remarkable increase at 60-min after the pump start, although there was no discernible difference in the incremental ratio of hemolysis following 240-min support. Therefore, our findings suggest that the leak rate and hemolysis are to be considered by the primary occlusion settings as well as the time-varying gap deformation for longer use of roller pumps.</p>"},{"@language":"ja","@value":"<p>Roller pumps are widely used as one of the cardiopulmonary bypasses during open-heart surgery. Hemolysis may cause acute kidney injury due to the changes in the tubing gap by the occlusion of roller pumps. In this study, we achieved the 3-D evaluation of the roller pump tubing gap for the first time by our originally developed visualization analysis. We examined the leak rate and the hemolysis under the 240-min circulatory support condition in a mock flow tester, and compared the tubing gap dimensions. As a result, the primary leak rate around 0.8 mL/min against 1 mH<sub>2</sub>O afterload significantly decreased after 60-min circulation, and there was no leak rate detected for 10 minutes measurement afterwards. The 3-D tubing gaps indicated that the subsidiary opening width at the short-axis edge decreased by more flattening shapes. Moreover, plasma free hemoglobin levels showed a remarkable increase at 60-min after the pump start, although there was no discernible difference in the incremental ratio of hemolysis following 240-min support. Therefore, our findings suggest that the leak rate and hemolysis are to be considered by the primary occlusion settings as well as the time-varying gap deformation for longer use of roller pumps.</p>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204239256579","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000351177782"},{"@type":"NRID","@value":"9000327099619"},{"@type":"NRID","@value":"9000283610753"},{"@type":"NRID","@value":"9000283611051"},{"@type":"NRID","@value":"9000376555584"},{"@type":"NRID","@value":"9000006478504"},{"@type":"NRID","@value":"9000017579323"},{"@type":"NRID","@value":"9000327099819"},{"@type":"NRID","@value":"9000327099499"},{"@type":"NRID","@value":"9000409012620"},{"@type":"NRID","@value":"9000283611110"},{"@type":"NRID","@value":"9000413383844"},{"@type":"NRID","@value":"9000345404900"},{"@type":"NRID","@value":"9000409859900"},{"@type":"NRID","@value":"9000327099623"},{"@type":"NRID","@value":"9000283611333"},{"@type":"NRID","@value":"9000283611067"},{"@type":"NRID","@value":"9000325831125"},{"@type":"NRID","@value":"9000021814664"},{"@type":"NRID","@value":"9000346923095"},{"@type":"NRID","@value":"9000347041260"},{"@type":"NRID","@value":"9000404144482"},{"@type":"NRID","@value":"9000327099547"},{"@type":"NRID","@value":"9000283610747"},{"@type":"NRID","@value":"9000325831144"},{"@type":"NRID","@value":"9000327099610"},{"@type":"NRID","@value":"9000327099505"},{"@type":"NRID","@value":"9000283611377"},{"@type":"NRID","@value":"9000023240550"},{"@type":"NRID","@value":"9000327099585"},{"@type":"NRID","@value":"9000257871428"},{"@type":"NRID","@value":"9000327099580"},{"@type":"NRID","@value":"9000327100234"},{"@type":"NRID","@value":"9000327100544"},{"@type":"NRID","@value":"9000405888813"},{"@type":"NRID","@value":"9000405888346"},{"@type":"NRID","@value":"9000405888384"},{"@type":"NRID","@value":"9000409859560"},{"@type":"NRID","@value":"9000283611220"},{"@type":"NRID","@value":"9000303992020"},{"@type":"NRID","@value":"9000327099554"},{"@type":"NRID","@value":"9000347042180"},{"@type":"NRID","@value":"9000398121483"},{"@type":"NRID","@value":"9000398121513"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/y_shiraishi"}],"foaf:name":[{"@language":"en","@value":"Shiraishi Yasuyuki"},{"@language":"ja","@value":"白石 泰之"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"東北大学加齢医学研究所"},{"@language":"en","@value":"Institute of Development, Aging and Cancer, Tohoku 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Akihiro"},{"@language":"ja","@value":"山田 昭博"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"東北大学加齢医学研究所"},{"@language":"en","@value":"Institute of Development, Aging and Cancer, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410011231093975297","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000304691983"}],"foaf:name":[{"@language":"en","@value":"Sahara Genta"},{"@language":"ja","@value":"佐原 玄太"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"東北大学大学院医工学研究科"},{"@language":"en","@value":"Graduate School of Biomedical Engineering, Tohoku 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Tomoyuki"},{"@language":"ja","@value":"山家 智之"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"東北大学加齢医学研究所"},{"@language":"en","@value":"Institute of Development, Aging and Cancer, Tohoku University"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801206724480","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20826060"},{"@type":"NRID","@value":"1000020826060"},{"@type":"NRID","@value":"9000002139799"},{"@type":"NRID","@value":"9000413383843"},{"@type":"NRID","@value":"9000409859909"},{"@type":"NRID","@value":"9000405888812"},{"@type":"NRID","@value":"9000405888345"},{"@type":"NRID","@value":"9000409859559"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/aoifukaya"}],"foaf:name":[{"@language":"en","@value":"Fukaya Aoi"},{"@language":"ja","@value":"深谷 碧"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Graduate School of Biomedical Engineering, Tohoku University"},{"@language":"ja","@value":"東北大学大学院医工学研究科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410011231093975298","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000413383847"}],"foaf:name":[{"@language":"en","@value":"Inoue Yusuke"},{"@language":"ja","@value":"井上 雄介"}],"jpcoar:affiliationName":[{"@language":"en","@value":"**Advanced Medical Engineering Research Center, Asahikawa Medical University"},{"@language":"ja","@value":"旭川医科大学先進医工学研究センター"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13419455"},{"@type":"EISSN","@value":"18845827"},{"@type":"NDL_BIB_ID","@value":"000000098701"},{"@type":"ISSN","@value":"13419455"},{"@type":"LISSN","@value":"13419455"},{"@type":"NCID","@value":"AA11947931"}],"prism:publicationName":[{"@language":"en","@value":"Journal of Life Support Engineering"},{"@language":"ja","@value":"ライフサポート"},{"@language":"en","@value":"Journal of Life Support Engineering"},{"@language":"ja","@value":"ライフサポート"},{"@language":"ja","@value":"エル・エス・ティ学会誌"},{"@language":"ja","@value":"ライフサポート学会誌"}],"dc:publisher":[{"@language":"en","@value":"The Society of Life Support Engineering"},{"@language":"ja","@value":"ライフサポート学会"}],"prism:publicationDate":"2021-06-30","prism:volume":"33","prism:number":"2","prism:startingPage":"52","prism:endingPage":"58"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/031605759"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I031605759"},{"@id":"https://www.jstage.jst.go.jp/article/lifesupport/33/2/33_52/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2021277489"}],"availableAt":"2021-06-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cardiopulmonary%20bypass","dc:title":"Cardiopulmonary bypass"},{"@id":"https://cir.nii.ac.jp/all?q=Roller%20pump","dc:title":"Roller pump"},{"@id":"https://cir.nii.ac.jp/all?q=Degree%20of%20occlusion","dc:title":"Degree of occlusion"},{"@id":"https://cir.nii.ac.jp/all?q=Hemolysis","dc:title":"Hemolysis"},{"@id":"https://cir.nii.ac.jp/all?q=Cardiopulmonary%20bypass","dc:title":"Cardiopulmonary bypass"},{"@id":"https://cir.nii.ac.jp/all?q=Roller%20pump","dc:title":"Roller pump"},{"@id":"https://cir.nii.ac.jp/all?q=Degree%20of%20occlusion","dc:title":"Degree of occlusion"},{"@id":"https://cir.nii.ac.jp/all?q=Hemolysis","dc:title":"Hemolysis"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257000283136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K18021"},{"@type":"JGN","@value":"JP19K18021"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18021/"}],"notation":[{"@language":"ja","@value":"ハイブリッド高度熱管理機構の構築により体内埋込型小児用肺循環補助装置を具現化する"},{"@language":"en","@value":"Bio-Device Hybrid Cooling System as Advanced Thermal Management for Pulmonary Circulation Assist 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